Cambridge Enterprise Limited

Smart Holograms Limited

Prometic Biosciences Inc.

Other

Promega Corporation

Al-urdonia Lemudaddat Al-ajsam Co

The Secretary of State for Defence in Her Britannic Majesty's Government

British Nuclear Fuels Plc

Cambridge University Technical Services Limited

The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland

Cambridge Sensors Limited

Paramata Ltd.

The United States of America As Represented by the Secretary of the State of Defence

Christopher Robin Lowe

Jeffrey Blyth

Satyamoorthy Kabilan

David James Squirrell

Peter J White

Anthony Peter James

Alexander James Marshall

Colin Alexander Bennett Davidson

Roger Bradley Millington

Adrian Carl Stevenson

James A H Murray

Khaled Mahmood Al-Qaoud

Laurence Carlo Tisi

Rachel Louise Price

Melenie Jane Murphy

Felicity Kate Sartain

Julie Tucker

Kim Hilary Lawden

Karishma Jain

Xiaoping Yang

Blanca Madrigal Gonzalez

Luay Fawzi Abu-Oatousch

Barry Burles

Penelope Agmad Shihab

Mei-Ching Lee

Neil C Bruce

Harry Eccles

Bernadette Yon-Hin

James Augustus Henry Murray

Saji S Eapen

Leonard H Smiley

Abid Hussain

Geoffrey William Garnham

James Augusts Murray

Dennis Lowik

Penelope Ahmad Shihab

Luay Fawzi Abu-Qatouseh

Gita Khalili Moghaddam

Abdel Monem Mohammad Rawashdeh

Yusuf Abdalsalam Alkhayyat

James McCann

Andrew Geoffrey Mayes

Quentin Tannock

Rachel Louise Leslie

Edward Rayne

Samer Sami Ratrout

Saleem Muneer Naser

Peter John White

Kathryn Elizabeth Sorrell Medlock

Adrian Martin Horgan

The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.

Holographic sensor

The present invention relates to a novel composition with milk of immunized camelid, particularly, () as the main component (i.e. active ingredient) and a method for the treatment or prevention of gastrointestinal infections, particularly, infections caused by(),(),(),, or. Said composition is prepared in the form of pharmaceutical, nutraceutical, or health food preparations. The present invention also discloses a process of preparing said composition.

Immunized camel milk-based composition for the treatment or prevention of gastrointestinal infections

The present invention relates to a novel pharmaceutical composition with milk of immunized camelid, particularlyas the main component (i.e. active ingredient) and a method for the treatment or prevention of skin or mucus membrane infections, particularly. The present invention also discloses a process of preparing said composition.

Camel milk-based topical pharmaceutical composition

A sensing system which comprises a material () formed of a matrix and a plurality of non-insulating particles () substantially equally spaced within the matrix such that the material has coherent electrical periodicity in at least one dimension; and a receiver (), the receiver arranged to receive a source RF signal and a returned RF signal, the source RF signal being reflected by the non-insulating particles to produce the returned RF signal. A change in the position of one or more of the non-insulating particles causes the returned RF signal to change, such that a change in a property of the material can be determined from the returned RF signal.

Sensing system and method

A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising the steps of: a) introducing a colloidal dispersion of a recording material into the support medium; and b) ablating the colloidal particles of the recording material using a pulsed laser to form the holographic element in the support medium. The method of production can be used to introduce a reflection holographic grating into a hydrophobic support medium, in particular, polydimethylsiloxane (PDMS), which possesses an extraordinary ability to swell in the presence of both liquid and/or gaseous low molecular weight hydrocarbons and organic solvents and thus has many applications as a holographic sensor.

Method of production of a holographic sensor

The present invention relates to a specific phenylboronic acid compound having anti-cancer, anti-inflammatory, and anti-microbial activity, in addition to a pharmaceutical composition comprising the same. The present invention also discloses a process for preparing said compound. The compound is represented by the formula (I): 

Phenylboronic acid

A sensing system comprises a material having a matrix structure in which a plurality of sensing elements are embedded, the sensing elements having electron distribution and/or transport properties that change in response to a change in a physical or chemical property of the material. The sensing system further comprises a receiver, including an antenna, the receiver arranged to receive a source RF signal and a returned RF signal, the returned RF signal being received from the material. A change in the electron distribution and/or transport properties of the sensing elements cause the source RF signal to change, such that a change in a property of the material can be determined from the returned RF signal. A corresponding method of sensing a change in a property of a material is also provided.

An isolated recombinant luciferase having luciferase activity. The recombinant luciferase has an amino acid sequence which differs from the wild-type luciferase fromor. In the sequence of the recombinant luciferase, the amino acid residue corresponding to phenylalanine 295 inwild-type luciferase or to leucine 297 inorwild-type luciferases, is mutated compared to the corresponding amino acid which appears in the corresponding wild-type luciferase sequence. The recombinant luciferase has increased thermostability compared to the corresponding wild-type luciferase.

Mutant luciferase

A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.

Boronate complex and its use in a glucose sensor

A sensor for the detection of an analyte, comprising a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the hologram changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the medium is obtainable by formation in situ in the presence of a pore-forming agent, wherein the agent is not present in the sensor or does not react with the analyte and the sensor.

Method for forming a volume holographic sensor in a porous medium

An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.

Ophthalmic device comprising a holographic sensor

The present invention pertains to compounds and polymers which incorporate a boronic acid sensor group (SG) of the formula (I): wherein: J is independently &#x2014;CH&#x2014; or &#x2014;CHCH&#x2014;; n is independently 0, 1, 2, or 3; and each R, if present, is independently a ring substituent; and wherein the ring attachment (i.e., where sensor group is attached) is via the 3-, 4-, 5-, or 6-ring position. Such compounds and polymers are useful in the selective chemical detection and/or quantitation of alpha-hydroxy carboxylic acids, such as lactic acid/lactate and malic acid/malate. The present invention also pertains to methods of preparing such compounds and polymers; methods and assays which employ these compounds and polymers; devices (e.g., holographic sensors) and kits for use in such methods and assays, etc. 

Sensor molecules incorporating a boronic acid sensor group

A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose. 

A sensor which comprises a support medium and a hologram disposed therein, wherein an optical characteristic of the medium varies as a result of a change of a property of the medium, and wherein the medium is heterogeneous such that the change of property is heterogeneous.

Holographic sensor having heterogeneous properties

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Cambridge, United Kingdom

Christopher Robin Lowe