Worcester Polytechnic Institute

Cercacor Laboratories, Inc.

Masimo Laboratories, Inc.

Christopher R Lambert

Jerome J Workman

Zhaolin Wang

Alex R Zelenchuk

Emile M Bellott

Hubert A Nienaber

Shirley J Shi

Dongsheng Bu

James J Childs

W Grant McGimpsey

John Benco

Robert L Coleman

Nantanit Wanichacheva

Venkat R Thalladi

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.

Non-invasive measurement of analytes

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

The present invention is a low-cost, easily deployed, degradable taggant that can be dispersed over a wide area to serve as a witness to activity in the area and for queuing of other sensors. The taggant enables nearly real-time change detection within the treated area using one or more simple optical sensing techniques.

Degradable taggant and method of making and using thereof

A compound sensitive to and selective for ammonium ions over other ions. A sensor fabricated from a self assembled monolayer of said compound on gold, exhibiting sensitivity and selectivity for ammonium ions over other ions in aqueous solutions, including blood. A method of preparation of said compound and said sensor.

Surface-based ammonium ion sensor and methods of making thereof

In various aspects are provided a microfluidic and/or nanofluidic sensor that can provide an indication of the reliability of its measurement of the presence of an analyte in a sample under investigation, an analyte concentration in the sample under investigation, or both. The provided sensors, microfluidic devices, and methods of analyte detection, utilize two transduction mechanisms from the same molecule to determine analyte presence, analyte concentration, or both. An analyte sensing molecule is used that can provide both an optical signal and electrochemical signal when an analyte is recognized by an analyte binding portion of the sensing molecule.

Multi-transduction mechanism based microfluidic analyte sensors

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Hudson, MA, United States of America

Christopher R Lambert