Astrazeneca Ab

Reviral Limited

Christopher Pilkington

Richard Angell

Neil Mathews

James Lumley

Malcolm Clive Carter

Stuart George Cockerill

Christopher James Wheelhouse

Alexander James Floyd Thomas

David John Bushnell

James Iain Salter

Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, &#x2014;(CH)&#x2014;, &#x2014;X&#x2014;, &#x2014;CH&#x2014;X&#x2014;, or &#x2014;X&#x2014;CH&#x2014;; X is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;N(R)&#x2014;, &#x3e;C&#x2550;O, &#x3e;S(&#x2550;O), &#x3e;S(&#x2550;O), &#x2014;O&#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;, N(R)&#x2014;C(&#x2550;O)&#x2014;, or &#x2014;C(&#x2550;O)&#x2014;N(R)&#x2014;; each L is independently a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl or Calkynyl, each of which is unsubstituted or substituted; each Z is independently &#x2014;N(R), &#x2014;OR, &#x2014;SR, &#x2014;S(&#x2550;O)R, &#x2014;S(&#x2550;O)R; each Ris independently hydrogen, Calkyl, Calkenyl or Calkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Pharmaceutical compounds

Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein.

Biphenyl derivatives and their use in treating hepatitis C

Growing community of inventors

London, United Kingdom

Christopher Pilkington