University of Iowa Research Foundation

Christopher Pigge

Michael K Schultz

Moustafa Tarek Ahmed Ibrahim Gabr

Mengshi Li

Moustafa Gabr

Mahboubeh Varmazyad

Prabhat C Goswami

Jessica Reedy

Edwin Sagastume

A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R-Ris independently selected from the group consisting of CHCOORand CHC(═O)NHR; each of R-Ris independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

Compositions for chelating metals at low temperatures

The invention provides a compound of formula (Ia) or (Ib): or a salt thereof, wherein A, B, C, D, E, F, J, K, L, M, Q, V, X, Y, W and Z have any of the values described in the specification, as well as compositions comprising a compound of formula (Ia) or (Ib) or a salt thereof, and methods of use thereof.

Dinuclear platinum(II) compounds and methods of use thereof

The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.

Image guided therapy for cancer

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Iowa City, IA, United States of America

Christopher Pigge