Merck Patent Gesellschaft MIT Beschraenkter Haftung

Cyclacel Limited

Merck Patent Gmbh

Sigma-aldrich Co. LLC

Intellikine LLC

Christopher Peter Worrall

Louise Diane Farrand

Owain Llyr Parri

Julian Scott Northen

Benjamin Mark Skead

Jonathan Charles Christian Atherton

Pingda Ren

Steven Tierney

Martin Heeney

Iain McCulloch

David Sparrowe

Mark Giles

Maxim Shkunov

Marcus Thompson

Michael Martin

Philippe Fernandes

Ian Victor Edward Hassall

Julian Frederick Samuel Vaughan-Spickers

Susanna Del Rio Gancedo

Philippe Fernades

Maxim Shkunow

Iain Mcculloch

The present invention relates to new crystalline forms of a purine derivative which exhibits excellent anti-tumor activity. The invention also relates to a pharmaceutical composition containing said crystalline forms as an active ingredient, and use thereof in the prevention or treatment of disease. The invention further relates to a process for preparing the crystalline forms.

Crystalline forms of a purine derivative

Polymorphs of chemical compounds that modulate kinase activity, including PI3K activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3K activity, are described herein.

Kinase inhibitor polymorphs

The present invention relates to new crystalline forms of a purine derivative which exhibits excellent anti-tumour activity. The invention also relates to a pharmaceutical composition containing said crystalline forms as an active ingredient, and use thereof in the prevention or treatment of disease. The invention further relates to a process for preparing the crystalline forms.

Described herein are compounds of formula Iwherein M, Mand Mhave the meanings recited in the disclosure, liquid crystalline mixtures and polymers containing them, and the use of the compounds of formula I, the liquid crystalline mixtures and the polymers containing them in optical and electrooptical devices like liquid crystal displays or projection systems, patterned films and optical elements like polarizers, retardation films, compensators, color filters, holographic elements or polarization beam splitters, for photoswitching, in anisotropic membranes for the permeation of gases or fluids, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic or pharmaceutical compositions, UV absorbers and sunscreens, diagnostics or liquid crystal pigments, for decorative and security applications, in nonlinear optics, optical information storage or as dopants.

Cycloalkanone derivatives

The invention relates to photoisomerizable compounds of formula Iwherein A, Z, L, R, R, k, m and r are defined herein.

Photoisomerizable compounds

Conjugated mono-, oligo- and polymers of benzo&lsqb;b&rsqb;thiophene and bisbenzo&lsqb;b&rsqb;thiophene are useful as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors, electroluminescent, photovoltaic and sensor devices.

Mono-, oligo- and polymers of benzo&lsqb;b&rsqb;thiophene and 2,2&prime;-bisbenzo&lsqb;b&rsqb;thiophene and their use as charge transport materials

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Northwich, United Kingdom

Christopher Peter Worrall