Boehringer Ingelheim Pharmaceuticals, Inc.

Christopher Pargellis

Neil Moss

Pier Francesco Cirillo

Eugene R Hickey

John R Regan

Abdelhakim Hammach

Charles Lawrence Cywin

Thomas A Gilmore

Victor Marc Kamhi

Paul S Riska

Disclosed are compounds of formula(I): wherein R, R, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Fluorinated di-aryl urea compounds

Disclosed are compounds of formula (I):wherein R, R, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

Aromatic heterocyclic compounds and their use as anti-inflammatory agents

Growing community of inventors

Redding, CT, United States of America

Christopher Pargellis