Bristol-myers Squibb Compnay

Christopher P Mussari

Dharmpal S Dodd

Alaric J Dyckman

Sreekantha Ratna Kumar

Laxman Pasunoori

Trevor C Sherwood

Subramanya Hegde

Shoshana L Posy

Tasir Shamsul Haque

John E Macor

Ramesh Kumar Sistla

Brian K Whiteley

David R Tortolani

Anupama Kandhi Ramachandra Reddy

Louis John Lombardo

Rushith Kumar Anumula

Michael A Poss

John L Gilmore

John S Tokarski

Srinivasan Kunchithapatham Duraisamy

Pitani Veera Venkata Srinivas

Ashvinikumar V Gavai

Wayne D Vaccaro

Daniel O'Malley

Tram N Huynh

Lalgudi S Harikrishnan

Ashok Vinayak Purandare

Muthoni G Kamau

William John Pitts

Stephen T Wrobleski

Chunjian Liu

John T Hynes

James M Lin

Rajeev S Bhide

Upender Velaparthi

Mark D Wittman

Derek J Norris

Yufen Zhao

Wen-Ching Han

Satheesh Kesavan Nair

George V Delucca

Peiying Liu

Venkatram Reddy Paidi

Shuqun Lin

Patrice Gill

Chetan Padmakar Darne

Claude A Quesnelle

Abhisek Banerjee

Louis J Lombardo

Selvakumar Kumaravel

Dibakar Mullick

Zhong Chen

Tasir Shamsul Hague

Anupama Ramachandra

Subramaya Hegde

Disclosed are compounds of Formula (I) or a salt thereof, wherein R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds useful as TLR inhibitors

4-azaindole compounds

Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds

N-oxides, or salts thereof, wherein G, L, R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Amide substituted indole compounds useful as TLR inhibitors

Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Aryl and heteroaryl substituted indole compounds

Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Amino indole compounds useful as TLR inhibitors

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, X, Y, Z, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Diazaindole compounds

Disclosed are compounds of Formula (I) or a salt thereof, wherein R, R, R, R, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors

[1,2,4]triazolo[1,5-A]pyridinyl substituted indole compounds

4-Azaindole compounds

Growing community of inventors

Princeton, NJ, United States of America

Christopher P Mussari