Wisconsin Alumni Research Foundation

Christopher P Churas

David Charles Schwartz

Michael A Newton

Konstantinos Dimitrios Potamousis

Rodney Runnheim

Daniel K Forrest

Galex S Yen

Shiguo Zhou

Steven J Goldstein

Konstantinos D Potamousis

Rodney A Runnheim

A computer database system for storing, processing, displaying, and analyzing single molecule data is capable of managing and processing variously formatted, different kinds of single molecule data and displaying subsets thereof upon instructions by a user. A component-based architecture is implemented where the processing and the displaying are separately performed. The data is dynamically loaded for processing as needed. Embodiments of computer database systems can be utilized in managing single molecule data, particularly image data derived from single molecule images. Such single molecule images may be generated by a variety of technologies, e.g., optical mapping, atomic force microscopy (AFM), scanning tunneling microscopy (STM), and flow cytometry. Systems may be deployed over a computer network. One or more additional databases may be included which are interconnected through a network.

Computer database system for single molecule data management and analysis

Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome.

Methods of whole genome analysis

Growing community of inventors

Madison, WI, United States of America

Christopher P Churas