G.d. Searle & Company

Other

Christopher P Carron

Debra M Meyer

George A Nickols

Jeffrey W Smith

Larry P Feigen

Neal F Haas

Jimmy D Page

Jodi A Pegg

Monoclonal antibodies that recognize the &agr;,&bgr;,integrin receptor complex, but do not significantly bind to &agr;,&bgr;,, can be used in methods for treating &agr;,&bgr;,integrin-mediated diseases, such as tunor metastasis.

Methods for using anti-&agr;v&bgr;3 integrin antibody

Monoclonal antibodies that recognize the &agr;,&bgr;,integrin receptor complex, but do not significantly bind to &agr;,&bgr;,, inhibit &agr;,&bgr;,integrin-mediated diseases.

Anti-&agr;v&bgr;3 integrin antibody antagonists

A method for determining the amount of an antiplatelet compound in a subject being treated with the compound which comprises calculating the ACT number of the subject's blood containing a reagent which immunoreacts with the antiplatelet compound and comparing the figure to a standardized concentration figure. In subjects concurrently being treated with heparin and antiplatelet compounds, the method can be practiced without additional heparin added to the blood sample. The invention also provides reagents which immunoreact with antiplatelet compounds and kits comprising immunoreactive reagents.

Method and reagent for monitoring blood levels of antiplantelet compounds

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Wildwood, MO, United States of America

Christopher P Carron