The United States of America, As Represented by the Secretary, Department of Health and Human Services

University System of Maryland

Christopher P Austin

Wei Ping Zheng

Juan Jose Marugan

Noel Terrence Southall

Ke Liu

Catherine Chen

Andrey Galkin

Liudmila Kulakova

Osnat Herzberg

Wei Zheng

This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of &#x3b4; tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of &#x3b4; tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of &#x3b4; tocopherol in combination with cyclodextrin to a patient in need thereof.

Use of delta tocopherol for the treatment of lysosomal storage disorders

Compounds useful for the treatment of giardiasis are described.

Methods of treating giardiasis

This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.

Growing community of inventors

Potomac, MD, United States of America

Christopher P Austin