Mosaic Technologies Inc.

Other

Walleye Technologies, Inc.

Whitehead Institute for Biomedical Research

Compellis Pharmaceuticals

Techtronic Power Tools Technology Limited

Matrix Technologies Corporation

Christopher P Adams

Stephen Joseph Kron

T Christian Boles

David S Holbrook

Ming X Wang

Andrew R Muir

James Flynn

Matthew J Mergener

John S Scott

Jeffrey Charles Hessenberger

Scott D Bublitz

Wolfgang Fink

Mark Huggins

Brent N Gregorich

Jason Porter Whitmire

John Cerwin

Umesh Rajani

Truett C Boles

Coimbatore Nagaraja Sridhar

Paul Adams Reaux

The present invention generally relates to apparatus, software and methods for assessing ocular, ophthalmic, neurological, physiological, psychological and/or behavioral conditions. As disclosed herein, the conditions are assessed using eye-tracking technology that beneficially eliminates the need for a subject to fixate and maintain focus during testing or to produce a secondary (non-optical) physical movement or audible response, i.e., feedback. The subject is only required to look at a series of individual visual stimuli, which is generally an involuntary reaction. The reduced need for cognitive and/or physical involvement of a subject allows the present modalities to achieve greater accuracy, due to reduced human error, and to be used with a wide variety of subjects, including small children, patients with physical disabilities or injuries, patients with diminished mental capacity, elderly patients, animals, etc.

Eye movement in response to visual stimuli for assessment of ophthalmic and neurological conditions

In one aspect, the present invention provides an imager, preferably portable, that includes a source of electromagnetic radiation capable of generating radiation with one or more frequencies in a range of about 1 GHz to about 2000 GHz. An optical system that is optically coupled to the source focuses radiation received therefrom onto an object plane, and directs at least a portion of the focused radiation propagating back from the object plane onto an image plane. The imager further includes a scan mechanism coupled to the optical system for controlling thereof so as to move the focused radiation over the object plane. A detector optically coupled to the lens at the image plane detects at least a portion of the radiation propagating back from a plurality of scanned locations in the object plane, thereby generating a detection signal. A processor that is in communication with the detector generates an image of at least a portion of the object plane based on the detection signal.

Electromagnetic scanning imager

In one aspect, a measurement system is disclosed that includes a source of microwave radiation having one or more wavelengths capable of penetrating through a visibly opaque obstruction, e.g., a wall. The source can be movably positioned on one side of the obstruction for illuminating thereof. The system can further include a microwave reflecting element disposed on another side of the obstruction, where the reflecting element is capable of reflecting at least a portion of the radiation transmitted through the obstruction. A plurality of radiation sensors are positioned relative to the obstruction so as to differentially detect at least a portion of the reflected radiation transmitted through the obstruction so as to determine a position of the source relative to the reflective element.

Microwave datum tool

The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical composition comprising an effective amount of a calcium channel blocker to the nasal mucosa, as well as screening methods for drugs to be used in treating obesity or associated disorders.

Inhibition of olfactory neurosensory function to treat eating disorders and obesity

Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.

Nucleic acid-containing polymerizable complex

This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.

Method and apparatus for performing amplification of nucleic acid on supports

Devices and methods for detecting the presence, or absence of the presence of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed.

Devices and methods for detecting target molecules in biological samples

A method has been developed which utilizes functionalized optical fibers as a solid support for the assembly of combinatorial libraries of compounds. The optical fibers are used to direct light, heat or a combination thereof to the compounds tethered to the fibers surface. Utilizing the method of the instant invention reactions occurring by both photochemically and thermally allowed pathways are accessible. In a preferred embodiment of the invention, the optical fibers are used to screen the array by fluorescence spectroscopy of labeled target molecules which bind to the immobilized library compounds.

Serially directed combinatorial synthesis on fiber optic arrays

Methods for treating injured corneal tissue are described. The methods include contacting injured corneal tissue with a contact lens which includes an amniotic composition such that scarring of the injured corneal tissue is reduced. Methods for conditioning a contact lens for treatment of injured corneal tissue are also described. The methods include contacting the contact lens with an amniotic composition whereby the amniotic composition is deposited in or on the surface of said contact lens. Additionally, contact lens packages for treatment of injured corneal tissue are described. The contact lens package includes a container holding a contact lens which includes an amniotic composition and instructions for using the contact lens for treatment of injured corneal tissue.

Biochemical contact lens for treating injured corneal tissue

Method for performing amplification of nucleic acid on supports

This invention features methods, apparatus and kits for performing nucleic acid hybridization and amplification reactions on a support. Such methods and apparatus are useful in diagnostic and therapeutic processes for synthesizing nucleic acid and detecting target nucleic acids in a sample.

Growing community of inventors

Somerville, MA, United States of America

Christopher P Adams