University of Ottawa

National Research Council of Canada

Syracuse University

Ottawa Hospital Research Institute

Christopher Noyce Boddy

Jean-Simon Diallo

Fabrice Le Boeuf

Dennis M Whitfield

Ian C Schoenhofen

Rozanne Arulanandam

Susan M Logan

Benjamin R Lundgren

Ramya Krishnan

Mark Dornan

Jeffrey Smith

Andrew Macklin

Anthony Garza

Provided are compounds of Formula III that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

Compositions and methods for viral sensitization

Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. 

The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-&#x3b2;-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-&#x3b1;-D-glucopyranose. Methods for producing the sugars are also provided.

Cell-based production of nonulosonates

The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-&#x25a1;-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-&#x25a1;-D-glucopyranose. Methods for producing the sugars are also provided.

A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts infor the production and discovery of secondary metabolites. Genomic DNA fromencoding the oxytetracycline biosynthetic pathway is inserted into the genome of the surrogate host. Thetranscriptional machinery recognizes and uses the streptomycetes promoter regions to express the biosynthetic enzymes. Co-expression inofoxytetracycline biosynthesis enzymes and, a key piece of thetranscriptional machinery, enablesto recognize and use the promoters from theoxytetracycline biosynthetic pathway, facilitating production of oxytetracycline.

System and method for the heterologous expression of polyketide synthase gene clusters

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Christopher Noyce Boddy