Other

Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

Christopher Norman Nilsen

Kirk L Sorgi

Michael Nicholas Greco

Michael Hawkins

Sergio Cesco-Cancian

Eugene Powell

Harold R Almond

Michael J Humora

Donald Gilmore Walker

Lawrence De Garavilla

Yun Qian

Mitul N Patel

Peter J Connolly

Anusuya Choudhury

Hongfeng Chen

The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Phosphonic acid compounds as inhibitors of serine proteases

The present invention is directed to a process for chemoselective substitution on a halopyrimidine carboxaldehyde having multiple reactive sites and subsequent stereoselective oxime formation.

Process for preparing substituted diaminopyrimidine oximes

Bolts detachably mount a thin tree-shearing blade on a peripheral reinforcing blade carrier swingably mounted on a tractor. The plunger of a hydraulic jack is connected directly to the blade, independently of the blade carrier, for swinging the blade to shear a tree. The force applied by the jack to the blade is applied in the plane of the blade. To prevent excess stress from being applied to the bolts connecting the blade and the blade carrier as a tree is sheared, the blade carrier includes projecting backing plates fitted against opposite edges of the blade for transmitting force applied to the blade directly to the blade carrier.

Tree shear blade structure

Conventional linkage projecting forward from a tractor, such as the linkage commonly used to support the bucket of a loader, carries a box frame for elevational movement and for tilting of the frame about a horizontal axis. Two sets of clamping grapple arms are mounted on cross members of the frame by upright pivot shafts extending between such cross members for swinging of the grapple arms. Jaws including shearing blades are mounted below the grapple arms between cross members of the frame for swinging about axes registered with the grapple arm axes. With the frame upright and the grapple arms and jaws open, the tractor is driven forward to embrace a standing tree between the grapple arms and the jaws. The grapple arms are closed to clamp the tree followed by closing the jaws to shear the tree, whereupon the tree, standing on the shearing blades, can be maneuvered in upright position to a piling or yarding area and swung downward by tilting the box frame forward.

Tree clamp and shear support structure

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Branchburg, NJ, United States of America

Christopher Norman Nilsen