Amgen Inc.

Other

Christopher Mohr

Neeraj Jagdish Agrawal

Kevin Graham

Kenneth William Walker

Agnes Eva Hamburger

Derek Evan Piper

Zhulun Wang

Cen Xu

Dante Romanini

Oliver Thiel

Alex W Jacobitz

Ray Lieh Yoon Low

Victoria Wagner

Stephen Smith

John K Kawooya

The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.

Bispecific antibodies with cleavable C-terminal charge-paired tags

The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Polynucleotides encoding monoclonal antibodies binding to human pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1) and methods of making thereof

Methods for treating a headache condition using anti-human PAC1 antibodies or antigen-binding fragments thereof

PAC1 antibodies and uses thereof

A device for mounting to the steering column of a golf cart for supporting and displaying looseleaf pages, in particular for displaying golf course information. The device includes a base for supporting pages generally perpendicular to the cart's steering column. A binder is secured to the base for holding the looseleaf pages and an attachment element is provided for mounting the device to the steering column of the golf cart.

Device for securing looseleaf pages on a golf cart steering column

An apparatus for mounting to a golf cart for supporting and displaying looseleaf pages, in particular for displaying golf course information. The apparatus includes a base for supporting looseleaf pages at an oblique angle relative to the cowl of the golf cart. A binder is secured to the base for holding the looseleaf pages and a first attachment element is provided for securing the base to the cowl at the edge. A second attachment element is provided for also attaching the base to the cowl. In a second preferred form, the apparatus is configured for mounting to the steering column of the golf cart, rather than to the cowl itself.

Apparatus for securing looseleaf pages to a golf cart

Boot

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Newbury Park, CA, United States of America

Christopher Mohr