Smithkline Beecham Corporation

Other

Affinium Pharmaceuticals, Inc.

Christopher Michael Traini

Richard Lloyd Warren

Min Wang

Michael Terence Black

Deborah Dee Jaworski

John Edward Hodgson

Michael Arthur Lonetto

Martin M Rosenberg

Judith M Ward

Leslie Marie Palmer

Jason Craig Fedon

Richard Oakley Nicholas

Magdalena Zalacain

David John Holmes

Raymond Winfield Reichard

Julie M Pratt

Sanjoy Biswas

James Raymond Brown

Karen Anne Ingraham

Anna Lisa Kosmatka

David Justin Charles Knowles

Christine Marie Debouck

Jeffrey L Mooney

Martin Karl Russel Burnham

Lisa Kathleen Shilling

Alison Francis Chalker

Yi Yi Zhong

Martin Karl Russell Burnham

Martin Karl Burnham

Damien McDevitt

Alison Frances Chalker

Thomas B Mathie

Elizabeth Jane Lawlor

Stephanie Van Horn

David Justin Knowles

David John Payne

Andrew P Fosberry

Jianzhong Huang

Chi Young So

Patrick Vernon Warren

Howard Kallender

John Peter Throup

Elizabeth J Lawlor

Martin K R Burnham

Marie J Mazzulla

Nicola Gail Wallis

Robert King Stodola

Michael N Gwynn

John Timothy Lonsdale

John E Hodgson

Daniel Robert Sylvester

Edwina Imogen Wilding

Karen M O'Dwyer

Tong Li

Xinhe Jiang

Joanna Lynn Fueyo

Chantal Myriam Petit

Pan Fong Chan

Glenn Scott Van Aller

Lisa Kathleen Katz

Chanal Myriam Petit

Yi Y Zhong

Lisa K Shilling Katz

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

Peptidyl t-RNA hydrolase (PTH)

The invention provides nrdF polynucleotides encoding nrdF polypeptides from and methods for producing such polypeptides by recombinant techniques. The invention also provides polynucleotides having high identity to the nrdF polynucleotides. Also provided are preferred methods for utilizing these polynucleotides and polypeptides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and materials.

NrdF from Staphylococcus aureus

The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.

lacR from Streptococcus pneumoniae

The invention provides Phosphatidylglycerophosphate Synthase polypeptides from (&ldquo;pgsA polypeptides&rdquo;). Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.

Phosphatidylglycerophosphate synthase from Staphylococcus aureus

The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.

PgsA

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.

inFB

The invention provides topA polypeptides and polynucleotides encoding topA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing topA polypeptides to screen for antibacterial compounds.

TopA

The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.

RibH

The invention provides respiratory nitrate reductase alpha subunit polypeptides and polynucleotides encoding respiratory nitrate reductase alpha subunit polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing respiratory nitrate reductase alpha subunit polypeptides to screen for antibacterial compounds.

Respiratory nitrate reductase alpha subunit

The invention provides dbpB polypeptides and DNA (RNA) encoding dbpB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dbpB polypeptides to screen for antibacterial compounds.

DbpB

The invention provides Novel ABC transporter polypeptides and polynucleotides encoding Novel ABC transporter polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Novel ABC transporter polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a novel ABC transporter

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Media, PA, United States of America

Christopher Michael Traini