Other

Pharmacopeia Inc.

N.v. Organon

Pharmacopela Drug Discovery, Inc.

Pharmacopeia Drug Discovery, Inc.

Christopher Mark Riviello

Jeffrey John Letourneau

Jagadish C Sircar

Ila Sircar

Dingwei Tim Yu

Orest Taras Macina

Patrick Anthony Jokiel

Koc-Kan Ho

Michael H Ohlmeyer

John Richard Morphy

Irina Neagu

Susan Elizabeth Napier

Jui-Hsiang Chan

John J Baldwin

Lawrence Wayne Dillard

Shawn David Erickson

Michael H J Ohlmeyer

James Inglese

Michael J Ohlmeyer

Angela Wong

Yaing Rong

Vidyahar Paradkar

Koc-Kan Hoc

Jui Hsiang Chan

Substituted pyridines, pyrimidines, pyrazines, pyridinones, pyrimidinones, pyrazinones and phenylacetamides useful in treating depression, stress and other disorders are disclosed. The compounds are of the formualae: Other embodiments are also disclosed.

Azinone and diazinone V3 inhibitors for depression and stress disorders

Disclosed herein are 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivative of formula I, or pharmaceutically acceptable salts or solvates thereof wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives according to the present invention and their use in therapy.

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The present invention relates to 2-(4-oxo4H-quinazolin-3-yl) acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression. 

2-(4-oxo-4H-quinazolin-3-yl)acetamides and their use as vasopressin V3 antagonists

Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity. Compounds of formula: are disclosed. A representative example is 

Nitrogen heterocycle biaryls for osteoporosis and other diseases

Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed. In one embodiment, the compounds are represented by Formula I,As selective inhibitors of inappropriate kinase activities, the compounds of the present invention are useful in the treatment of conditions associated with such activity, including, but not limited to, inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting inappropriate kinase activities and methods of treating conditions associated with such activities.

Pyrimidine and triazine kinase inhibitors

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

Class of thiomorpholino substituted thiazoles

Class of piperazino substituted thiazoles

Oxadiazole antifungal agents

Diaryl substituted thiazoles useful in the treatment of fungal infections

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Morrisville, PA, United States of America

Christopher Mark Riviello