Worcester Polytechnic Institute

Advanced Cell Technology, Inc.

Christopher Malcuit

Tanja Dominko

Marsha W Rolle

Fioleda Prifti

Denis Kole

Terri Anne Camesano

Raymond L Page

The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

Matrix scaffold with antimicrobial activity

The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.

Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies

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Kent State, OH, United States of America

Christopher Malcuit