Medtronic, Inc.

Warsaw Orthopedic, Inc.

Mozarc Medical US LLC

Other

Bellco S.r.l.

Christopher M Hobot

Martin T Gerber

Bryant J Pudil

Vanja Margareta King

William F McKay

Phillip Edward McDonald

John Myers Zanella

Kathy L Remsen

Danielle L Biggs

Amira Wohabrebbi

Katara Shaw

David B Lura

Orhan Soykan

Keith Robert Hildebrand

VenKatesh R Manda

Michael Eric Benz

Randall V Sparer

Thomas Edward Meyer

Arthur J Coury

Kanjimpuredathil Muralikrishna Menon

Stephen Mark Cox

James R Keogh

Ramkumar Jeyachandran

Suping Lyu

Allan H Jevne

Edward D DiDomenico

Kaustubh R Patil

David L Miller

Matthew A Bergan

John W Eaton

Troy Carter

Sukalyan Dutta

Kelvin Bonnema

Kenneth C Gardeski

Mark Allan Tapsak

Kenneth B Stokes

Carl A Schu

Daniel Cheek

Douglas Dean Nippoldt

Linda L Ruetz

Narayanan Ramamurthy

Wei Qin

Qingshan (Sam) Ye

David A Pearson

Randy Meyer

Vitally G Sitko

Andrew J Ries

John E Burnes

Kenneth Timothy Heruth

Jeffrey Mendel Gross

Joseph F Lessar

James F Kelley

Paul A Pignato

Mark D Breyen

Robert M Skime

Stanten C Spear

Mark S Lent

Sean M Haddock

Kenneth Boone Wagener

Michael Jay Ebert

William Jeffrey Bertrand

Maura G Donovan

Richard D Sandstrom

Jin Huang

John W Kramer

Ruchika Singhal

William L Johnson

Rebecca L Poindexter

Scott J Brabec

Edward Di Domenico

Roland C Maude-Griffin

Mahesh Parameswaran

James A Coles, Jr

Anthony R Rorvick

Phong D Doan

Warren W Howland

Rohit Kumar Narula

Daniel Bloomberg

Eric A Grovender

William J Hooper

Steven G Rockow

Vitaly G Sitko

Norma K Bullock

Kiem Dang

Edward D Di Domenico

Lian Leon Luo

Krishnaraja Nellikunje

Vijaya Kumar Parari

John E Schwendeman

Bryantl J Pudil

Jennifer L Braunschweig

Michael D Benz

S Mark Cox

Edward Phillip McDonald

Kurt Carlson

Sujeendran Malayath

Brian A Loy

Sameer Saxena

K Matthew Kinnane

System and methods for sensing fluid characteristics of peritoneal dialysate infused into and removed from a patient during treatment are provided. The systems and methods can use an optical sensor including a transmitter light source operable to emit light through a fluid flow path and an optical receiver operable to receive at least a portion of the light emitted by the transmitter light source.

Dextrose concentration sensor for a peritoneal dialysis system

The invention relates to systems and methods for generation and use of peritoneal dialysis fluid. The peritoneal dialysis fluid is generated by dissolving solids or diluting concentrated liquids in a single container having all components of the final peritoneal dialysis fluid.

Single container preparation of peritoneal dialysis fluid

The invention relates to devices, systems, and methods for preforming a precision dialysis therapy session based on an analysis of an effluent from a zirconium phosphate sorbent module during an ammonium removal process. The settings for the precision dialysis therapy session can be obtained by estimating a patient's physiological state, such as BUN level, based on the analysis of the effluent for a particular sorbent module linked to a particular patient.

Precision dialysis therapy based on sorbent effluent analysis

The invention relates to systems and methods for sensing fluid characteristics of peritoneal dialysate infused into and removed from a patient during treatment. The systems and methods include sensors, processors, and flow paths for determining patient health based on the fluid characteristics of the peritoneal dialysate. The system can be a peritoneal dialysis cycler which can include an infusion line; an effluent line; at least one pump positioned in the infusion and/or effluent line; and at least one sensor fluidly connected to the effluent line. The sensor can be at least one of a flow sensor, an ion selective electrode, a pH sensor, a pressure sensor, a refractive index sensor, and a temperature sensor. The method can include infusing peritoneal dialysate through an infusion line; removing peritoneal dialysate through an effluent line; and determining at least one fluid characteristic of the peritoneal dialysate in the effluent line.

Peritoneal dialysate flow path sensing

The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the peritoneal cavity of the patient. The method can include infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient; monitoring one or more patient parameters; and adjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using an on-line peritoneal dialysis machine. The system can include a peritoneal dialysis cycler.

Peritoneal dialysis intracycle osmotic agent adjustment

The invention relates to systems and methods for disinfecting, recharging, and conditioning zirconium phosphate in a reusable sorbent module. The systems and methods provide for reuse of a zirconium phosphate sorbent module after dialysis.

Zirconium phosphate disinfection recharging and conditioning

The invention relates to devices, systems, and methods for measuring dialysis adequacy in patients undergoing peritoneal dialysis treatment. The devices, systems, and methods use one or more flow sensors and one or more solute sensors to measure the concentration of a uremic solute and volume of the peritoneal dialysate removed from the patient, and to calculate the dialysis adequacy based on the measured peritoneal dialysate concentration and volume.

Peritoneal dialysis adequacy meaurements

The invention relates to devices, systems, and methods for performing a precision or personalized Peritoneal Dialysis (PD) therapy session or cycle based on dialysis adequacy measurements in patients undergoing peritoneal dialysis treatment. The settings for the precision peritoneal dialysis therapy session can be obtained using one or more flow sensors and one or more uremic solute sensors that measure the uremic solute concentration and volume of the peritoneal dialysate removed from the patient. The desired dialysis adequacy for a specific patient, group of patients, or class of patients, can then be calculated based on the measured peritoneal dialysate concentration and volume. Using the calculated dialysis adequacy, the system and methods can then set one or more peritoneal dialysis parameters for subsequent cycles or sessions.

Precision peritoneal dialysis therapy based on dialysis adequacy measurements

The invention relates to a testing system and related methods for detecting peritonitis or infection in peritoneal dialysate removed from a patient. The testing system can include a fluid sensor apparatus in a fluid line of a peritoneal dialysis cycler through which spent peritoneal dialysate can be pumped. The fluid sensor apparatus can detect one or more markers associated with peritonitis or infection.

Peritoneal dialysis fluid testing system

A stacked sorbent assembly for use in sorbent dialysis. The stacked sorbent assembly contains two or more interchangeable sorbent pouches that allow for fluid to freely pass into and through the sorbent materials, while keeping the sorbent materials inside the sorbent pouches. Any of the pouches in the sorbent cartridge can be reused and/or recharged.

Stacked sorbent assembly

The invention relates to devices, systems, and methods for conditioning a zirconium oxide sorbent module for use in dialysis after recharging. The devices, systems, and methods can provide for conditioning and recharging of zirconium oxide in a single system, or in separate systems.

Zirconium oxide module conditioning

The invention relates to devices, systems, and methods for precision recharging of sorbent materials in a sorbent module. The devices, systems, and methods use manufacturing characteristics of the sorbent module to set recharge parameters used in recharging the sorbent material.

Precision recharging based on sorbent module manufacturing characteristics

The invention relates to devices, systems, and methods for recharging zirconium phosphate and/or zirconium oxide in reusable sorbent modules. The devices, systems, and methods provide for precision recharging of the zirconium phosphate and/or zirconium oxide to avoid the need of excess recharge solutions. The devices systems and methods also provide for calculation of the volumes of recharge solution needed for fully recharging the zirconium phosphate and zirconium oxide modules.

System for precision recharging of sorbent materials using patient and session data

The invention relates to devices, systems, and methods for mixing one or more solutions to generate a recharge solution having specified concentrations of a sodium salt and acid for recharging and disinfecting zirconium phosphate in reusable sorbent modules. The devices, systems, and methods can generate a recharge solution by a sorbent recharger that is introduced through the sorbent module to recharge and to disinfect the zirconium phosphate.

Recharge solution for zirconium phosphate

The invention relates to an infusate holder for use in dialysis. The infusate holder can include one or more interior compartments for holding infusate containers or infusates. The interior compartments are aligned to cooperate with fluid connectors of a dialysis system, ensuring that the proper infusates are added to the dialysis system at a proper location.

Infusate holder

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Tonka Bay, MN, United States of America

Christopher M Hobot