Darwin Discovery Limited

Other

Chiroscience, Ltd.

Ucb Pharma, S.a.

Seiko Epson Corporation

Christopher Lowe

John Gary Montana

Hazel Joan Dyke

Andrew Sharpe

Verity Margaret Sabin

Alan Findlay Haughan

George Martin Buckley

Hannah Jayne Kendall

William Ross Pitt

Stephen Robert Mack

Marianna Dilani Richard

Nicholas J Allen

Natasha Kinsella

Laura Jane Tait

Graham John Warrellow

Rikki Peter Alexander

Daniel Christopher Brookings

Julien Alistair Brown

Roland W Bürli

Stephen Brand

Piero Migliorato

Stuart Bailey

Daniel Rees Allen

Richard John Davenport

Duncan Robert Hannah

Andrew James Ratcliffe

Christopher James Lock

Robert James Maxey

Rajinder S Sethi

Karen Ann Runcie

Catherine Louise Picken

Nathan Bavidge

John Richard Davenport

Louise Picken

Jack Brettle

Sophie Caroline Williams

A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula 

Quinoxaline and quinoline derivatives as kinase inhibitors

A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Fused thiophene derivatives as kinase inhibitors

A sensor cell comprises receiving means, which may be in the form of an electrode coupled to the gate electrode of a thin film transistor T In one form of the invention a voltage supplied to the gate electrode of the transistor T via a switching transistor T is controlled in dependence upon the value of capacitance C arising at the electrode from receipt of a sample for identification. Thus, the operation of transistor T can be used to identify the sample received by the electrode

Sensor cell

Heterocyclic compounds and their therapeutic use

A compound of formula (i) ##STR1## has therapeutic utility via inhibition of phosphodiesterase and THF release.

Benzofuran-4-carboxamides and their therapeutic use

Compounds having the formula (i), ##STR1## wherein the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined herein. The compounds of the present invention can be utilized to treat disease states capable of being modulated by inhibition of proteins which mediate cellular activity, such as tumor necrosis factor (TNF) and/or phosphodiesterase IV (PDE IV).

Benzofuran carboxamides and their therapeutic use

The subject invention concerns novel compounds of the general formula (i) ##STR1## that are useful in treating disease states, such as those states associated with proteins that mediate cellular activity. The compounds of the subject invention can be used, for example, to inhibit tumor necrosis factor and/or phosphodiesterase IV, The subject invention also concerns methods for treating disease states using the compounds of the invention.

Quinoline carboxanides and their therapeutic use

Benzofuran carboxides and sulphonamides have therapeutic utility, e.g. in the treatment of inflammation and asthma, by virtue of their ability to inhibit phosphodiesterases and tumor necrosis factor.

Benzofuran sulphonanmides

3,4-Disubstituted-phenylsulphonamides have therapeutic utility via TNF or phosphodiesterase inhibition.

3,4-disubstituted-phenylsulphonamides and their therapeutic use

A dispensing device for a soluble or dispersible material is disclosed, which device comprises a tube formed of a liquid-impermeable material and of unitary construction, the tube being closed at both ends and having perforations along a portion of its length at or close to one end, and containing a soluble granular material. Preferably the lower end of the tube has a flattened, paddle-like portion, and the perforations are arranged linearly along opposite sides of the tube aligned with the edges of the flattened portion. The tube is advantageously divided into two compartments by a temporary seal; in this way, the material can be kept in one compartment which is free from perforations until the device is to be used.

Dispensing device for soluble or dispersible material

Chromatographic separation device

A dispensing device for a soluble granular material is disclosed, which device comprises a tube formed of a liquid-impermeable material and of unitary construction, the tube being closed at both ends and having perforations along a portion of its length at or close to one end, and containing a soluble granular material. Preferably the lower end of the tube has a flattened, paddle-like portion, and the perforations are arranged linearly along opposite sides of the tube aligned with the edges of this flattened portion.

Dispensing device for soluble granular materials

Growing community of inventors

Cambridge, United Kingdom

Christopher Lowe