Mitralign, Inc.

Edwards Lifesciences Corporation

Becton Dickinson and Company Limited

Christopher Lee

Michael W Sutherland

Megan E Holmes

Steven D Cahalane

James M Sellers

Aaron M Call

Richard J Morrill

Jason Robinson

Jonathan L Goodwin

John DePiano

Edward I McNamara

Adam Vigneault

Paul A Spence

Joseph P Lane

Hiroatsu Sugimoto

Michael R Cole

Jayeon Kim

John Alexander

Mathew S Cardinali

Gregory Kenny

Donald S Baim

Richard D Hudson

Nareak Douk

Morgan House

Kate E Cutuli

Matt Guimond

Dennis M Goodine

Jonathan Goodwin

A syringe adapter includes a housing having a first end and a second end positioned opposite the first end, with the housing defining a passageway, and a connector body having a first end and a second end positioned opposite the first end, with the connector body having a connection member configured to be secured to a mating connector. One of the housing and the connector body includes a tab and the other of the housing and the connector body defines a channel that receives the tab, with the connector body movable relative to the housing between a first position where the connector body is restricted from rotating relative to the housing in a first rotational direction and free to rotate relative to the housing in a second rotational direction, and a second position where the connector body is free to rotate in the first and second rotational directions.

Syringe adapter with secure connection

A plication lock delivery system that enables a suture lock assembly to be delivered percutaneously. The plication lock delivery system comprises a lock assembly that secures sutures in place, a control assembly that allows a clinician to engage a suture to a suture lock assembly, apply tension to the sutures to cause tissue plication, and deploy the lock assembly, and a catheter assembly. This plication lock delivery system can be used to repair mitral regurgitation percutaneously or in an open-heart surgery.

Plication lock delivery system and method of use thereof

The present teachings provide devices and methods of locating a mitral valve commissure, and implanting tissue anchors at or near the mitral valve commissure. Specifically, one aspect of the present teachings provides devices and methods for locating a mitral valve commissure percutaneously and allowing a guide wire to be placed across a mitral annulus at the mitral valve commissure. Another aspect of the present teachings provides methods for deploying a tissue anchor across a mitral annulus at a mitral valve commissure, including near the Por Pregions of the posterior mitral annulus. Another aspect of the present teachings further provides methods of plicating a mitral annulus between two or more tissue anchors.

Devices and methods for locating and implanting tissue anchors at mitral valve commissure

The present teachings generally relate to translation catheter systems and method of using thereof in treating defective mitral valves. Specifically, a translation catheter system includes a catheter configured to move substantially laterally along the mitral annulus and the lateral movement of the catheter is substantially continuous and substantially adjustable. Accordingly, a method of using such a translation catheter includes advancing a first wire across the mitral annulus at a first treatment location, delivering a catheter at or near the first treatment location, moving the catheter substantially laterally to a second treatment location, and advancing a second wire across the mitral annulus, where the distance between the first and second treatment locations is substantially adjustable and optionally visualized.

Translation catheters, systems, and methods of use thereof

A plication lock delivery system that enables a suture lock assembly to be delivered percutaneouly. The plication lock delivery system comprises a lock assembly that secures sutures in place, a control assembly that allows a clinician to engage a suture to a suture lock assembly, apply tension to the sutures to cause tissue plication, and deploy the lock assembly, and a catheter assembly. This plication lock delivery system can be used to repair mitral regurgitation percutaneouly or in an open-heart surgery.

The present teachings provide devices and methods of treating a tricuspid valve regurgitation. Specifically, one aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distances between two papillary muscles. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distances along the right ventricle wall. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distance between the distance of right ventricle outflow track and the right ventricle wall. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by changing the right ventricle sphericity index. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the tricuspid valve tethering height.

Percutaneous valve repair by reshaping and resizing right ventricle

A tissue anchoring system includes a tissue anchor member that is suitable for anchoring against tissue. The system also includes a tensioning member operatively connected to the anchor member such that the anchor member can slide relative to the tensioning member, the tensioning member capable of being pulled to cause the anchor member to move relative to the tensioning member into a position seated against the tissue. A hand operated deployment catheter is operable to extend and deploy the anchor member therefrom. The deployment catheter includes a rotatable member about which the tensioning member is routed and a clutch assembly for limiting tension within the tensioning member to prevent the deployed anchor from being pulled through the tissue.

Hand operated device for controlled deployment of a tissue anchor and method of using the same

A system is provided for delivering respective anchors into spaced apart locations along an annulus of a mitral valve. The system includes a first catheter member having a first lumen formed therein for receiving a first guide wire and also includes a second catheter member that is configured to move between an expanded position and a collapsed position relative to the first catheter member. The second catheter member has a lumen formed therein for receiving a second guide wire when the second catheter member is in the expanded position. The second catheter member is fixedly connected to the first catheter member by a first connector (that defines first and second living hinges) which is configured to deploy under a select condition to automatically cause the second catheter member to move to the expanded position.

Systems and methods for introducing elements into tissue

A locker for securing one or more tensioning members and a method of using the same is described. The locker includes a locker body having a passageway through which tensioning members extend. A movable member is coupled to the locker body and traverses the passageway. The movable member is movable between a latent position within the passageway in which the one or more tensioning members are movable relative to the locker body and an activated position within the passageway in which the one or more tensioning members are locked relative to the locker body. A hub surrounds the locker body such that the locker body is retractable with respect to the hub. Retraction of the locker body causes the movable member to move distally from the first position to the second position.

Device for percutaneously delivering a cardiac implant through the application of direct actuation forces external to the body

Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.

Growing community of inventors

Tewksbury, MA, United States of America

Christopher Lee