Argonaut Technologies, Inc.

Christopher Kilcoin

Terry D Long

Steve Miller

James Richard Wasson

Jan Hughes

Devices and methods are provides for delivering fluids into reaction vessels. The present device is an interface head which allows a user to add reagents and wash solvents to a reaction vessel. Typically, the interface head can engage a plurality of these reaction vessels mounted in a cassette or frame and is adapted to removably engage passages leading into the reaction vessel. The interface head allows a user to manually inject materials into the plurality of passageways in the head which are fluidly coupled to the reaction vessel. In one embodiment, the interface head has a septa valve which opens and closes inlets of the plurality of passageways. The septa valve comprises an elongate member with a septum portion and a plurality of septum ports. The elongate member is slidable between a first position wherein at least one inlet of the passageways in the interface head is sealed by the septum portion and a second position wherein said at least one inlet is aligned with one of the ports to allow delivery of materials from the inlet into the reaction vessel. The septum portion is penetrable by needles and thus allows access for needle/syringe type delivery devices.

Devices and methods for accessing reaction vessels

Systems and methods for synthesizing chemical compounds using a plurality reaction vessels. In particular, the present invention provides a synthesis apparatus capable of holding a plurality of reaction vessels for parallel synthesis of multiple discrete compounds or for combinatorial libraries of compounds. In one embodiment, a synthesis apparatus comprises a frame having a plurality of reaction vessel-holding openings and a plurality of valves for use in parallel synthesis of a plurality of compounds within reaction vessels.

Systems and methods for parallel synthesis of compounds

A closure device (4) is used to seal an opening of a vessel (6), while providing access to the interior of the vessel. The closure device automatically releases gas and/or toxic vapor from the sealed vessel to protect the operator from harmful vapor without requiring the operator to manually actuate a valve or other mechanism prior to removing the vessel from the closure device. The closure device is constructed so the interior of the vessel can be pressurized while maintaining a pressure seal against the vessel opening, and the vessel can be cannulated without overpressurizing the vessel interior.

Closure device and method for venting, cannulating and pressurizing a

A closure device (4) and a method for sealing an opening of a vessel (6), while providing access to the interior of the vessel. The device also provides a method for automatically releasing gas and/or toxic vapor from the sealed vessel to protect the operator from harmful vapor without requiring the operator to manually actuate a valve or other mechanism prior to removing the vessel from the closure device. In addition, the device provides a method for pressurizing the interior of the vessel while maintaining a pressure seal against the vessel opening and a method for cannulating the vessel without overpressurizing the vessel interior.

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Los Altos Hills, CA, United States of America

Christopher Kilcoin