Hauser, Inc.

Hauser Chemical Research, Inc.

Other

The Johns Hopkins University

Dovetail Technologies, Inc.

Whistle Shield LLC

Natural Pharmaceuticals, Inc.

Christopher K Murray

Qun Y Zheng

Randall J Daughenbaugh

Gary H Posner

Jeffrey T Beckvermit

Theresa A Shapiro

Poonsakdi Ploypradith

S Kent Peterson

Floyd E Taub

Daniel Lednicer

Sagar R Shakya

David T Bailey

Xiaoqin Cheng

Michael H Parker

Soon Hyung Woo

Timothy D Ziebarth

Suji Xie

Hardwin O'Dowd

Binyamin Rothstein

Thomas J Perun

Dominick J Anziano

Lynn G Darbie

Viatcheslav Orlov

John Northrop

Ryan Martin

John Stratiou

Jeffrey S Elias

Adam M Flore

Quy Y Zheng

A whistle is structured for promoting hygienic use of the whistle and for maximizing inlet air pressure to generate sound from the whistle. The whistle includes an air inlet having a channelizer for dividing and channeling air flow received from the air inlet through at least two different channels. A sound-generating chamber is in corresponding fluid communication with each of the channels, and an air exhaust is in fluid communication with the sound-generating chamber. The air exhaust is structured and located on the whistle body for generating a sound, and is positioned and structured at a location suitable for directing air flow away from the air exhaust in a generally downwardly and/or opposing direction with respect to a generally horizontal air flow direction at the air inlet.

Hygienic whistle with enhanced sound-generating chamber

A device for receiving and holding a plurality of objects comprises a main body having a plurality of chambers defined therein and a plurality of resilient tabs attached to or integral with the main body and spaced about a perimeter of the main body. Each chamber has an open top end and is adapted to receive at least one object via its open top end. Each tab is adapted to support the device on a top rim of a bucket such that the main body is elevated off a floor of the bucket. Each tab is adapted to flex inward toward a longitudinal axis of the main body when a downward force is applied to the main body such that the main body and the tabs move downward into the bucket until the main body contacts the floor of the bucket.

Caulk caddy and corresponding method and system

7-hexanolytaxol and methods for preparing the same

Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same

The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

Low molecular weight cell, bone marrow and immune stimulants

7-hexanoyltaxol and methods for preparing the same

The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A&mdash;B&mdash;C&mdash;S&mdash;S&mdash;D&mdash;E&mdash;F, wherein: A and F are selected from the group consisting of hydrogen, an amino acid, a dipeptide, a tripeptide, a modified polypeptide up to three amino acids long, and a carbobenzoxy groups, B and E are selected from the group consisting of an amino acid, a dipeptide, a tripeptide, and a modified polypeptide comprising up to and including three amino acids, C and D are selected from the group consisting of a modified polypeptide and a polypeptide comprising up to and including three amino acids, and S is the sulfur atom in the modified polypeptide and the polypeptide in C and D.

Disulfides and thiol compounds

Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure

Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same

The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes; or when n is 3, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.

C-10 carbon-substituted artemisinin-like trioxane compounds having

The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.

An antitumor compound of formula (5) ##STR1## and also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2' and 7 positions of paclitaxel is followed by the hydrolysis of the 2' hexanoate group resulting in 7-hexanoyltaxol.

Methods of inducing immunity using low molecular weight immune stimulants

Novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.

Trioxane dimer compounds having antiproliferative and antitumor

An antitumor compound of formula (5) ##STR1## in which R is Ac or H, and R.sub.1, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.3 is H; R.sub.1 and R.sub.2 and R.sub.3 are H; R.sub.1 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.2, R.sub.3 is H; R.sub.1 and R.sub.3 are H, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 is H, R.sub.2 and R.sub.3 are an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 and R.sub.2 and R.sub.3 are an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.

Cephalomannine epoxide, its analogues and a method for preparing the same

Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.

Growing community of inventors

Longmont, CO, United States of America

Christopher K Murray