Smithkline Beecham Corporation

Glaxo Wellcome Inc.

Christopher John Wallis

Martin Francis Jones

Michael John Dawson

Barry Riddle Sickles

Mahmoud Mahmoudian

Kenneth James Ingold

John Frederick Seager

Alastair Couper Brodie

The present invention relates to a process for the preparation of a carbocyclic purine nucleoside analogue of formula (I), its salts and pharmaceutically acceptable derivatives thereof which comprises hydrolysing a compound of formula (IV) wherein P is a protecting group, in the presence of an acid, condensing the product of formula (V) formed in situ in the presence of a base with a compound of formula (VI) followed by in situ ring closure of the resulting intermediate.

Process for the synthesis of chloropurine intermediates

The present invention relates to a process for the preparation of enantiomerically enriched N-derivatized (1R,4S)-2-azabicyclo&lsqb;2.2.1&rsqb;hept-5-en-3-ones by use of an enzyme.

Process for preparing enantiomerically enriched N-derivatized lactams

The hemisulfate salt of (1S,4R)-cis-4-&lsqb;2-amino-6-(cyclopropylamino)-9H-purin-9-yl&rsqb;-2-cyclopentene-1-methanol or a solvate of it is used in the treatment of viral infections.

Carbocyclic nucleoside hemisulfate and its use in treating viral infections

Process for resolving mixtures of carbocyclic stereoisomers

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Stevenage, United Kingdom

Christopher John Wallis