Auckland Uniservices Limited

Guangzhou Institute of Biomedicine and Health

Christopher John Squire

Jeffrey Bruce Smaill

Ke Ding

Adam Vorn Patterson

Swarnalatha Akuratiya Gamage

Zhengchao Tu

Amir Ashoorzadeh

Christopher Paul Guise

Xiaomei Ren

Matthew Roy Bull

Paul Gary Young

Xueqiang Li

Shuang Jiang

Angus Cheverton Grey

Maria Rosaria Abbattista

Edward Neill Baker

Yuliana Yosaatmadja

The invention relates to protein ligation technologies, purified or recombinant peptides, methods for making peptides and proteins with covalent bonds including reversible covalent bonds such as reversible intermolecular covalent bonds, and uses thereof. In particular, this invention relates to intermolecular ester bonds, particularly reversible ester bonds between the hydroxyl and amide groups of amino acid side chains present in recombinant chimeric peptides and proteins and the use of such peptides and proteins in protein engineering, for example in the preparation of multimeric protein complexes, including functionalised multimeric protein complexes.

Methods for protein ligation and uses thereof

Fibroblast Growth Factor Receptor kinase inhibitors and prodrugs thereof of Formula (I) and their use for the treatment of hyper-proliferative diseases such as retinopathy, psoriasis, rheumatoid arthritis, osteoarthritis, septic arthritis, tumour metastasis, periodontal disease, corral ulceration, proteinuria, coronary thrombosis from atherosclerotic plaque, aneurismal aorta, dystrophobic epidermolysis bullosa, degenerative cartilage loss following traumatic joint injury, osteopenias mediated by MMP activity, tempero mandibular joint disease, and demyelating disease of the nervous system.

FGFR kinase inhibitors and pharmaceutical uses

Growing community of inventors

Auckland, New Zealand

Christopher John Squire