Cincinnati Children's Hospital Medical Center

University of Cincinnati

Christopher John Lindsell

Hector R Wong

Shelia Salisbury

Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in pediatric patients. In particular, the invention relates to identifying two or more biomarkers associated with septic shock in pediatric patients, obtaining a sample from a pediatric patient having at least one indication of septic shock, then quantifying from the sample an amount of two or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome.

Septic shock endotyping strategy and mortality risk for clinical application

Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in pediatric patients. In particular, the invention relates to identifying one or more biomarkers associated with septic shock in pediatric patients, obtaining a sample from a pediatric patient having at least one indication of septic shock, then quantifying from the sample an amount of one or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome.

Temporal pediatric sepsis biomarker risk model

The invention provides a multi-biomarker based methods to stratify adult septic shock patients into high and low risk groups.

Multi-biomarker-based outcome risk stratification model for adult septic shock

The invention provides multi-biomarker based methods to stratify pediatric septic shock patients into high and low risk groups.

Growing community of inventors

Cincinnati, OH, United States of America

Christopher John Lindsell