Provalis UK Limited

Cortecs (uk) Limited

Christopher John Kirby

Roger Randal Charles New

Roger Randal New

Single phase preparations of hydrophilic species, in particular macromolecular compounds such as proteins or glycoproteins in a hydrophobic solvent such as an oil can be obtained by preparing a hydrophile/amphiphile array in which the hydrophilic head groups of the amphiphile are orientated towards the hydrophilic species and bringing the array into contact with the hydrophobic solvent. The preparations of the invention can be used alone or can be combined with an aqueous phase to form emulsions in which the hydrophilic species is present in the hydrophobic phase. The compositions of the present invention are versatile and have application in the pharmaceutical, food, cosmetic, chemical and agricultural industries.

Hydrophobic preparations of hydrophilic species and process for their preparation

Hydrophobic preparations which are useful as, among other things, pharmaceutical delivery systems comprise: (i) an oil phase comprising one or more medium chain monoglycerides, such as Akoline MCM&trade;; (ii) at least one amphiphile, preferably including a phospholipid such as phosphatidyl choline; and (iii) a hydrophilic species, which may be a protein such as insulin or calcitonin or another macromolecule, solubilized or otherwise dispersed in the one or more glycerides. The hydrophilic species is one that is not normally soluble in the glycerides.

Hydrophobic preparations containing medium chain monoglycerides

The invention provides a process for the preparation of a single phase hyudrophobic preparation comprising a hydrophilic species in a hydrophobic solvent wherein a compound which is:

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Berkshire, United Kingdom

Christopher John Kirby