Chdi Foundation, Inc.

Respivert Limited

Evotec International Gmbh

Christopher John Brown

Celia Dominguez

Peter David Johnson

Michael Edward Prime

John Wityak

Jonathan Bard

Daniel Clark-Frew

Sarah Hayes

Frederick Arthur Brookfield

Kazuhiro Ito

John King-Underwood

Peter John Murray

George Hardy

Samuel Coe

Thomas Martin Krülle

Alex Kiselyov

Stephen Martin Courtney

Leticia M Toledo-Sherman

William Mitchell

Paula C De Aguiar Pena

Matthew Robert Mills

Paul Richard Giles

Sébastien René Gabriel Galan

Thomas Martin Krulle

Richard Waldron Marston

Duane Higgins

Samantha Brown

Daryl Simon Walter

Holly Atton

James Lindsay Carr

Elise Luciennen Paulette Gadouleau

Scott Alexander Sadler

Jonathan Paul Shine

Longbin Liu

Ignacio Muñoz-Sanjuán

Matthew Randolf Lee

Christopher Francis Palmer

Serge Convers-Reignier

Inaki Morao

Ignacio Muñoz-Sanjuan

Michael Corr

Marissa Flower

Irena Reboule

Adrian Kotey

Elise Lucienne Paulette Gadouleau

Malcolm George Taylor

Ian James Wigginton

Derek Alexander Weddell

Mohamad Sabbah

Ignacio Munoz

Peter Johnson

Michael Prime

Sebastien Rene Gabriel Galan

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, R, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Modulators of the integrated stress response pathway

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, X, X, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Probes for imaging huntingtin protein

Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

Compounds and probes for imaging huntingtin protein

Probes for imaging Huntingtin protein

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. 

Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use. 

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use 

The present invention relates to the compound of formula (I) and to compositions comprising the same and to the use of the compound and to compositions of the compound in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compound.

Quinazolin-4 (3H)-one derivatives used as P13 kinase inhibitors

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Abingdon, United Kingdom

Christopher John Brown