Becton Dickinson and Company Limited

Hoya Corporation

E2, LLC

Koninklijke Philips Corporation N.v.

Fractyl Health, Inc.

Fractyl Laboratories, Inc.

Electrocore, Inc.

Passport Technologies, Inc.

Christopher James Kadamus

Serge Cyril Roux

Harith Rajagopalan

Robb M Gavalis

Marc Graham

George McGee Perkins

Mark A Manasas

David Gale

Buket Grau

Sam Anne Musgrave

Stephen J Irwin

Mark Jeffrey Edhouse

R Maxwell Flaherty

Jay D Caplan

Andrew Owen Coats

Eric Bené

J Christopher Flaherty

Russell S Cole

Justin Edward Rothermel

Chad Zediker

Steven Charles Stegman

Hrishikesh Vishvas Deo

Isaac Ostrovsky

Keith Aaron Grider

Richard Thomas Haibach

Azadeh Khanicheh

Gabor Zanoni

Eric Bene

Nathan Gregg Barr

Craig Morris Gardner

Philip Stephen Levin

Anh Minh Do

Robert Earl Hieber

Mark Bui Breneman

Uros Kascak

Bernadette Messier

James Pelletier

Arvin Abadilla

Nicholas H Tran

Andrew Hollett

Charles Abele

Thomas Kochem

Sara Morneau

Jeffrey Johnson

Stephen James Irwin

Robb Morse Gavalis

Bernadette C Messier

Michael Biasella

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

Injectate delivery devices, systems and methods

A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.

Tissue expansion devices, systems and methods

The device of the present invention comprises an intervening release liner as a common special feature, and the intervening release liner covers a part of an adhesive surface of a patch. The intervening release liner gets away from the patch, and is fixed to a patch application support (or porator tab). Due to such constitution, under a situation in use where the first part of the adhesive area of the patch adheres to a skin surface, the patch application support is slidable along the skin surface while peeling the intervening release liner from said part of the adhesive area of the patch to adhere to the skin surface.

Transdermal permeant application device

Embodiments of the present disclosure are directed to apparatuses, devices, and methods for connecting a device to an endoscope. In one implementation, an apparatus for connecting a device to an endoscope includes a multi-tined connector and a locking sleeve. The multi-tined connector is configured to engage with a port of an endoscope having a non-circular flange. The multi-tined connector includes a body portion and a plurality of tines connected to the body portion. The body portion has a lumen axially extending therethrough and an outer locking interface. The tines are radially deflectable, have outer tapered surfaces, and operate between an engaged position and a disengaged position, wherein in the engaged position, the tines engage with the port. The locking sleeve operates between a locked position and an unlocked position. In the locked position, the locking sleeve holds the tines in the engaged position, and in the unlocked position, the locking sleeve leaves the tines in the disengaged position.

Apparatuses and methods for endoscopic connection

Locking sleeve

Embodiments of the present disclosure are directed to apparatuses, devices, and methods for locks for endoscopic accessories. In one implementation, an adjustable lock for an endoscopic accessory includes a body slidably mounted upon a rail of the endoscopic accessory, and an arm extending about a portion of the body. The arm may be connected to the body and pivotable relative to the body between a closed position and an open position. In the closed position, teeth on an inner surface of the arm may engage a toothed rack on the rail such that the adjustable lock is secured to the rail. In the open position, the teeth on the inner surface of the arm may be clear of the toothed rack such that the lock may slide relative to the rail.

Adjustable endoscopic locks

Adjustable lock

Embodiments of the present disclosure are directed to apparatuses, devices, and methods for secure connections between tubular structures. In one implementation, a first tube constructed of nitinol may have windows formed on an end thereof. A second tube constructed of stainless steel tube may be inserted within the first tube, and the windows may be filled with adhesive or solder. The adhesive or solder may bond with the first tube, forming connection pins which secure the tubes together. In some embodiments, the connected tubes may form an endoscopic needle. The nitinol portion of the needle may be sufficiently flexible for positioning within the bending section of an endoscope without deformation. The stainless steel portion of the needle may render the needle significantly less expensive than prior needles constructed solely of nitinol.

Apparatuses and methods for endoscopic tool joints

An infusion set has a partially integrated ballistic inserter that can insert a needle at a controlled rate of speed to a depth to deliver content to the upper 3 mm of skin surface, and a skin-securing adhesive layer to secure the skin surface at the insertion site such that the inserter that can insert a needle with a reduced risk of tenting of the skin surface. A removable turnkey or pushable handle can be provided to release a driving spring of the ballistic inserter to insert a needle at a controlled rate of speed, of 3.3 ft/sec. (1.0 m/sec.) up to and including those greater than 10 ft/sec. (3.0 m/sec.), then release from the set for disposal. The infusion set can further include an extendable interface ring that retracts when the inserter is removed from the infusion set.

Insulin pump dermal infusion set having partially integrated mechanized cannula insertion with disposable activation portion

An infusion set has an integrated ballistic inserter that can insert a needle at a controlled high rate of speed to a depth to deliver content to the upper 3 mm of skin surface, and a skin securing, adhesive layer to secure the skin surface at the insertion site such that the inserter that can insert a needle without a risk of tenting of the skin surface. A driving spring of the ballistic inserter is captured within the ballistic inserter, and can be released by user operation, to insert a needle at such a controlled rate of speed.

Integrated spring-activated ballistic insertion for drug delivery

A patient interface device () includes a patient sealing assembly () adapted to communicate a flow of breathing gas within an airway of a patient, the patient sealing assembly including a cushion (), a frame member () coupled to the cushion, and an adjustable forehead support assembly () coupled to the frame member. The adjustable forehead support assembly includes a forehead cushion () and an inflatable and deflatable bladder () coupled to the forehead cushion, wherein inflation and deflation of the bladder causes the distal end () of the frame member to move relative to the forehead cushion in a manner wherein a pressure applied to a bridge of a nose of the patient by the cushion is adjusted.

Patient interface device including a pneumatically adjusting forehead support

Growing community of inventors

Jamaica Plain, MA, United States of America

Christopher James Kadamus