Spiration, Inc.

Christopher J Thralls

Hugo Xavier Gonzalez

Brandon J Shuman

Clinton Lee Finger

Jean-Martin Baillargeon

Peter D Hoffman

A device for tissue sampling that comprises a needle, a stylet and a sealing member. The needle comprises a distal tip, a proximal end, and one or more interior portions. The needle extends along a longitudinal axis extending between the distal tip and the proximal end. The stylet is moveably supported within the one or more interior portions of the needle. The sealing member Is moveably supported within the one or more interior portions of the needle and substantially conforms to the one or more interior portions, The distal tip is configured to obtain a tissue sample. The stylet and the sealing member are movable, along the longitudinal axis away from the distal tip so that a local vacuum is created at the distal tip so that obtained tissue samples can be aspirated into the needle.

Device for creating a local vacuum at a distal end of a sampling device

Embodiments disclosed herein are directed to devices, methods, and systems for the treatment of tissue using energy delivery. Specifically, certain embodiments may utilize a thermochemical reaction between at least two reagents where a first reagent has been preloaded into a catheter while a limiting reagent is circulated through the catheter to react with the first reagent. The resulting chemical reaction may be exothermic or endothermic, and a heat transfer fluid may be used to exchange energy between the chemical reaction and surrounding tissue.

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Kirkland, WA, United States of America

Christopher J Thralls