Rosetta Inpharmatics, Inc.

The Netherlands Cancer Institute

Merck Sharp + Dohme Corp.

Peter S. Linsley

Yudong He

Mao Mao

Christopher J. Roberts

Hongyue Dai

Van De Vijver, Marc J.

Van't Veer, Laura Johanna

Rene Bernards

A. A. M. Hart

Laura Johanna Van't Veer

Marc J. Van De Vijver

Christopher J Roberts

Peter S Linsley

HongYue Dai

Marc J Van De Vijver

Augustinus A M Hart

Aa M Hart

A A M Hart

Laura Johanna VAN'T Veer

The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Diagnosis and prognosis of breast cancer patients

The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also provides methods of classifying and treating patients based on prognosis. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the diagnostic, prognostic and statistical methods disclosed herein.

Methods of assigning treatment to breast cancer patients

The present invention relates to genes in,which are essential for germination and proliferation of,and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticides, herbicides and anti-proliferation drugs. The present invention provides antisense molecules and ribozymes comprising sequences complementary to the sequences of mRNAs of essential genes that function to inhibit the essential genes. The present invention also provides neutralizing antibodies to proteins encoded by essential genes that bind to and inactivate the essential gene products. The present invention further provides pharmaceutical compositions for treating fungal and proliferative diseases, as well as methods of treatment of fungal and proliferative diseases.

Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs

Growing community of inventors

Seattle, WA, United States of America

Christopher J Roberts