University of Colorado

Christopher J Moody

David B Ross

David R Siegel

Philip Reigan

Wenchang Guo

Donna Dehn

Christopher S P McErlean

David Siegal

Marie A Colucci

Russell Richard Anthony Kitson

David Ross

Christopher Sp Mcerlean

The invention provides indole-4,7-dione derivatives useful for the treatment of diseases in a mammal, pharmaceutical compositions containing the same and methods of using the same in the treatment of cancer and neoplastic diseases including human solid tumors and other mammalian tumors.

Indole derivatives and methods of using the same

The invention provides 19-substituted geldanamycin derivatives, and pharmaceutically acceptable salts thereof that are potent Hsp90 binding agents useful for the treatment of, and/or the amelioration of symptoms of, cancer or neurodegenerative disorders.

HSP90 inhibitors with modified toxicity

The invention provides 19-substituted geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents useful for the treatment of, and/or the amelioration of symptoms of, cancer and other proliferative tissue disorders.

Hsp90 inhibitors with modified toxicity

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Leicestershire, United Kingdom

Christopher J Moody