Hoffmann-La Roche Inc.

Christopher J Moody

Cedric H Hassall

Geoffrey Lawton

Intermediates of the formula ##STR1## wherein A is methylene, ethylene or propylene which may be substituted by lower alkyl, Y is halogen, R.sup.3 is hydrogen, lower alkyl, aryl or aryl-(lower alkyl)--, R.sup.20 l is lower alkoxy and R.sup.42 is hydrogen, lower alkyl, aryl or aryl-(lower alkyl) or a group of the formula --A--Y in which A and Y are as above, are described.

Intermediates for pyrazolopyridazine derivatives

Compounds of the formula ##STR1## wherein A is methylene, ethylene or propylene which may be substituted by lower alkyl, B is carbonyl or methylene, R.sup.1 is halogen, carboxyl, lower alkoxycarbonyl, hydroxyaminocarbonyl, mercapto, lower alkanoylthio or aryl(lower alkylthio)--, R.sup.2 is hydroxy, lower alkoxy or amino, R.sup.3 is hydrogen, lower alkyl, aryl or aryl(lower alkyl)--, R.sup.4 is hydrogen, lower alkyl, aryl, aryl-(lower alkyl)-- or a group of the formula --A-R.sup.1 wherein A and R.sup.1 are as described above and the broken line denotes an optional carbon-carbon bond which can be present only when B is carbonyl, and salts of the acids of formula I with pharmaceutically acceptable bases, a process for the manufacture thereof and pharmaceutical preparations containing same, are described. The compounds of formula I and their salts are useful as antihypertensive agents.

Pyrazolopyridazine antihypertensives

The present invention relates to pyridazopyridazine derivatives, a process for the preparation thereof, pharmaceutical preparations containing said derivatives and the use of said derivatives as antihypertensive agents.

Pyridazopyridazine derivatives

The present disclosure is directed to 1-substituted or unsubstituted lower alkylene, 5-carboxy, alkanoyloxy or carbamoyloxy triazolopyridazine derivatives, salts of the acids and pharmaceutically-acceptable bases thereof. The triazolopyridazine derivatives provided by the present invention are useful as angiotensin-related antihypertensive agents.

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Stevenage, United Kingdom

Christopher J Moody