Mayo Foundation for Medical Education and Research

Christopher J Krco

Eugene D Kwon

Keith L Knutson

Haidong Dong

Lynn C Hartmann

Kimberly R Kalli

Svetomir N Markovic

Xin Liu

Susan M Harrington

Materials and methods for treating cancer, including materials and methods for treating cancer in patients identified as having elevated levels of Bim.

Methods for treating cancer in patients with elevated levels of Bim

This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR&#x3b1; immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.

Immunity to folate receptors

Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.

Methods for treating cancer in patients with elevated levels of BIM

This document provides methods and materials involved in treating cancer. For example, methods and materials for identifying a mammal as having an elevated level of PD-1/CD11aCD8 T cells having the potential to exert anti-cancer effects are provided. In addition, methods and materials for identifying a mammal as having an elevated level of PD-1/CD11aCD8 T cells and administering a PD-1 inhibitor to such a mammal are provided.

Growing community of inventors

Rochester, MN, United States of America

Christopher J Krco