Pfizer Corporation

Christopher J Dutton

Stephen Paul Gibson

Bernard Joseph Banks

Alexander C Goudie

Nigel D Walshe

David Morris Gethin

Ivan Tommasini

Richard Edward Armer

Shih-Jen E Lee

Michael John Witty

Douglas James Critcher

Julian Duncan Smith

Kimberley Verrier

4-arylpiperidine derivatives for the treatment of pruritus

Novel compounds having general formula (I), and pharmaceutically and veterinarily acceptable salts thereof wherein R , R , R , W, Y , Y , X, n and y are as defined above and processes for their preparation and intermediate compounds prepared therein. The novel compounds are useful for having utility in the treatment of pruritic dermatoses including allergic dermatitis and atopy in animals and humans.

4-phenylpiperidines for the treatment of pruritic dermatoses

Antiparasitic agents

Antiparasitic avermectin derivatives of formula (I), where the broken line represents an optional bond, R.sup.1 and R.sup.4 are independently H, OH, halo, oximino, or an organic radical, R.sup.2, R.sup.6 and R.sup.7 are organic radicals and R.sup.3 is alpha-oleandrosyl or 4'-(alpha-oleandrosyl)-alpha-oleandrosyl optionally substituted at the 4'- or 4'-position, and R.sup.12 and R.sup.13 are independently H, CN, CONH.sub.2, C.sub.1 -C.sub.8 alkyl or aryl optionally substituted with at least one halo, OH, C.sub.1 -C.sub.8 alkylthio group.

Antiparastic auermectin derivatives

Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R.sup.1 is H or OH; provided that when X is a single bond, R.sup.1 is H or OH, and when X is a double bond, R.sup.1 is absent;

Process for preparing antiparasitic agents

Benzimidazole anthelmintics

This invention is directed to certain 2-(alkoxycarbonylamino)- and 2-(alkoxycarbonylimino)benzlmidazole derivatives which are useful in the topical, oral or parenteral treatment of animals suffering from helminth infections.

Benzimidazole anthelmintic agents

##STR1## Benzimidazole anthelmintic agents of formula (I) and their non-toxic salts in which R is H, CO.sub.2 (C.sub.1 -C.sub.10 alkyl), --CO.sub.2 (cholester-3-yl) or --CO.sub.2 (CH.sub.2)COOH or --CO.sub.2 (CH.sub.2).sub.n CO.sub.2 (C.sub.1 -C.sub.6 alkyl), n=1 to 10, R.sup.1 is optionally substituted benzoyl, phenyloxy, phenylthio, phenyisulfonyl, phenylsulfinyl, phenylsulfonyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl or is selected from a variety of heterocyclic groups and R.sup.2 and R.sup.3 are independently --CO.sub.2 (C.sub.1 -C.sub.4 alkyl).

Antiparasitic compounds of formula (I): ##STR1## The broken line at the 22-23 position representing an optional double bond and either R.sup.1 is H or OH and the double bond is absent or the double bond is present and R.sup.1 is absent; R.sup.2 is optionally substituted phenyl, or a group of formula (II): ##STR2## wherein X is O, S or --CH.sub.2 --, abc and d are 0-2 and a+b+c+d.ltoreq.5 R.sup.3 is H or Me

Method for making antiparasitic agents

Antiparasitic compounds of formula (I): ##STR1## The broken line at the 22-23 position representing an optional double bond and either R.sup.1 is H or OH and the double bond is absent or the double bond is present and R.sup.1 is absent; R.sup.2 is optionally substituted phenyl, or a group of formula (II): ##STR2## wherein X is O, S or --CH.sub.2 13 , abc and d are 0-2 and a+b+c+d.ltoreq.5

Antiparastic agents

Antiparasitic compound of formula (I): ##STR1## The broken line at the 22-23 position representing an optional double bond and either

Growing community of inventors

Sandwich, United Kingdom

Christopher J Dutton