Baylor College of Medicine

European Molecular Biology Laboratory

Envivo Pharmaceuticals, Inc.

Vitruvean LLC

Christopher J Cummings

William Charles Ripka

Huda Y Zoghbi

Luis Serrano

Juan Botas

Cayetano Gonzalez

Christian Boulin

Edward Faeldt

David A Lowe

The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.

Method for identification of biologically active agents

The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.

Compounds for treatment of neurodegenerative diseases

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Brookline, MA, United States of America

Christopher J Cummings