Treventis Corporation

Denovamed Inc.

Denouamed, Inc.

Christopher J Barden

Fan Wu

Erhu Lu

Mark A Reed

Donald F Weaver

Thomas Kuchurean Wood

Michael D Carter

Shengguo Sun

Scott C Banfield

Arun Yadav

Thomas K Wood

Methods for identifying compounds that are inhibitors or are likely to be inhibitors of amyloid protein aggregation, as well as three-dimensional, non-crystallographic models (i.e. 'pseudo-crystal structures') of amyloid aggregation utilized in the methods, are described. Means for creating the three-dimensional, non-crystallographic models (i.e. 'pseudo-crystal structures') of amyloid aggregation are also described.

Methods for identifying inhibitors of amyloid protein aggregation

Compounds or pharmaceutical acceptable salts thereof of Formula (I), in which RM have the meaning described herein and pharmaceutical compositions thereof useful as antimicrobial and/or adjuvant: 

Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial

In general, among other things, compounds of Formula I are provided: in which Ris e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N,N,N-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; Ris, e.g., phenyl optionally substituted with one or more substituents; and Rand Rare each independently hydrogen or alkyl. Methods of treatment are also provided.

Anti-amyloid compounds containing benzofurazan

In general, among other things, compounds of Formula I are provided: in which Ris selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; Ris selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, etc.; and Rand Rare each independently hydrogen or alkyl. Methods of treatment are also provided.

Benzofurazan anti-amyloid compounds and methods

Among other things, in general, antimicrobial and/or adjuvant compounds are provided according to Formula Ia: (Ia) in which E and R1-11 have the meanings described herein; and prodrugs and pharmaceutically acceptable salts thereof. Other formulae and methods of use are also provided. 

Antimicrobial/adjuvant compounds and methods

The present invention is directed to compounds that inhibit amyloid aggregation and methods of treatment therewith.

Growing community of inventors

Toronto, Canada

Christopher J Barden