The University of Edinburgh

Christopher Haslett

Mark Bradley

Nikolaos Avlonitis

Neil Alexander McDonald

Annamaria Helena Lilienkampf

Marc Vendrell Escobar

Kanwaldeep Dhaliwal

Timothy Simon Walsh

A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.

Molecular probes for detecting gram-negative bacteria in vitro and in vivo

A probe for detecting bacteria and/or fungi in vitro and in vivo is provided, the probe having a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and having a fluorophore and a binding moiety, wherein the binding moiety is a bacteria binding moiety and selectively binds to bacteria and/or to fungi and not to animal cells. Methods of use of the probe and kits comprising the probe are also provided.

Fluorescent polybranched probes for detecting bacteria and/or fungi in vitro and in vivo

Growing community of inventors

Edinburgh, United Kingdom

Christopher Haslett