Stem Cell Therapeutics Inc.

Christopher Gregg

Samuel Weiss

Linda Andersen

Emeka Enwere

Allen Davidoff

Joseph Tucker

The present invention relates to a method to increase oligodendrocytes and oligodendrocyte precursor cells through administration of prolactin or a prolactin inducing agent.

Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin

The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using a pheromone, a luteinizing hormone (LH) and/or a human chorionic gonadotrophin (hCG). The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from or suspected of having neurodegenerative diseases or conditions.

Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

The present invention provides effective dosing regimes for neural stem cell proliferating agents, kits containing effective dosing regimes for neural stem cell proliferating agents, and uses thereof. In particular, neural stem cell proliferating agents, such as hCG, prolactin and EPO are delivered to mammalian subjects at low doses in a continuous fashion over several days, as opposed to delivery of high doses in a short period of time.

Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents

Effective dosing regimens for neural stem cell proliferating and differentiating agents, kits comprising effective dosing regimens for neural stem cell proliferating and differentiating agents, and uses thereof are provided herein. Such kits and methods can be utilized acutely or chronically to treat a neurodegenerative disease or condition. Furthermore, the compositions and methods can be used continuously or intermittently in various dosing regimens.

Dosing regimens for neural stem cell proliferating agents and differentiating agents for the treatment of neurological disorders

Oligodendrocyte precursor cell proliferation regulated by prolactin

The present invention relates to a method of producing radial glial cells from neural stem cells, particularly by contacting neural stem cells with epidermal growth factor (EGF), fibroblast growth factor 2 (FGF-2) and/or TGF&#x3b1;. Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) can optionally be added to enhance the effect of EGF, FGF-1 or TGF&#x3b1;. Also provided are methods of producing radial glial cells from ependymal cells, as well as methods of proliferating ependymal cells.

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Cambridge, MA, United States of America

Christopher Gregg