Genentech, Inc.

Christopher G Rudman

Arthur J Ammann

Theodore J Hahn

A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF-.beta. and a source of osteogenic cells in a pharmaceutically acceptable carrier.

Method of inducing bone growth using TGF-.beta.

TGF-.beta. composition for inducing bone growth

A method is disclosed for at least partially restoring normal growth, weight gain, and lean body mass of a mammal afflicted with glucocorticoid excess. This method comprises the administration to the mammal of an effective amount of IGF-I. Preferably, the mammal is a child and the IGF-I is native-sequence or brain IGF-I.

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San Francisco, CA, United States of America

Christopher G Rudman