Virginia Commonwealth University

Zoetis Services LLC

Christopher G Earnhart

Richard Thomas Marconi

Zhichang Xu

Patrick F M Meeus

Lee D Oliver

Jason John Millership

Robert M Lohse

Chimeric polyvalent recombinant proteins for use as vaccines and diagnostics for Lyme disease (e.g. in canines and humans) are provided. The chimeric proteins comprise epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types and/or OspE types. The OspC types may be associated with mammalianinfections.

Polyvalent chimeric OspC vaccinogen and diagnostic antigen

Antigenic polypeptides comprising linear immunodominant epitopes ofouter surface protein A (OspA) orouter surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detectinginfections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from bothOspA andOspC.

Lyme disease vaccine

The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein ofand a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and/or protecting dogs from Lyme disease using the vaccines are also provided.

Vaccines and methods to treat lyme disease in dogs

A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammaliraninfections.

Polyvalent chimeric OSPC vaccinogen and diagnostic antigen

A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammalianinfections.

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Spotsylvania, VA, United States of America

Christopher G Earnhart