Imperial Chemical Industries Limited

Christopher G Booth

Raymond C Rowe

A method of administering less than 20 .mu.l of a solution of an ophthalmically effective substance to the eye characterized in that the formulation has a viscosity and resistivity which makes it suitable for electrodynamic spraying, and the formulation is supplied to a spray nozzle wherein a sufficiently large electrical potential, relative to earth, is applied to the formulation that a sufficient electrical gradient is provided at the spray nozzle to atomize the formulation as a spray of electrically charged droplets. Also liquid solution formulations of opthalmically effective substances for use in the method of the invention; and electrodynamic spraying apparatus, convenient for hand held use, for use in the method of the invention.

Ocular treatment

A method of administering less than 20 .mu.l of a solution of an ophthalmically effective substance to the eye characterized in that the formulation has a viscosity and resistivity which makes it suitable for electrodynamic spraying, and the formulation is supplied to a spray nozzle wherein a sufficiently large electrical potential, relative to earth, is applied to the formulation that a sufficient electrical gradient is provided at the spray nozzle to atomize the formulation as a spray of electrically charged droplets. Also liquid solution formulations of ophthalmically effective substances for use in the method of the invention; and electrodynamic spraying apparatus, convenient for hand held use, for use in the method of the invention.

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Middlesbrough, United Kingdom

Christopher G Booth