Imperial Chemical Industries Limited

Zeneca Limited

Christopher F Hayward

Anand Swaroop Dutta

John S Morley

Gilbert J Stacey

James J Gormley

Ronald Cotton

Roger Camble

Alan F Hawkins

Terence R Owen

Nigel N Petter

A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises:

Peptide process

The invention relates to a polypeptide of formula I:

Bombesin antagonists with deletion of net-residue at the C-terminus

The disclosure relates to novel polypeptides which possess analgesic activity, to processes for their manufacture and to pharmaceutical compositions containing them. Typical of the peptides disclosed is: ##STR1##

Polypeptide

This invention provides a method of enhancing, or preventing the decline in, the digestibility of a crop, in particular of a fodder crop, by applying to the crop, to seed of the crop, or to the locus of the crop or seed, a compound or a mixture of at least two compounds of general formula (I) ##STR1## wherein R is hydrogen or --COR.sup.1 wherein R.sup.1 is alkyl, aryl, aralkyl, alkoxy, aryloxy or aralkyloxy, X is --O--, --NE-- or --CH.sub.2 --, Y is carboxy or an alkali metal, ammonium or mono- or di-alkyl- or cycloalkylamine salt thereof, or Y is alkoxycarbonyl, aryloxycarbonyl, aralkyloxy- carbonyl, amino or mono- or di-alkyl- or aryl- amino, Z is hydrogen, halogen, nitro, alkyl, trihalomethyl, hydroxy, alkoxy, acyloxy, cyano or alkylenedioxy, and x is an integer of 1 to 3. The invention also provides novel compounds, namely L-.alpha.-aminooxy-.beta.-(parahydroxy phenyl) propionic acid, and acid addition salts thereof.

Method of improving or maintaining digestibility of fodder crops

The disclosure relates to novel polypeptides which possess analgesic and sedative activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is

Growing community of inventors

Macclesfield, United Kingdom

Christopher F Hayward