Vanderbilt University

Christopher E Nelson

Craig L Duvall

Mukesh Kumar Gupta

Scott A Guelcher

Jeffrey M Davidson

John R Martin

Kristin P O'Grady

James Kintzing

Joshua M Shannon

Elizabeth J Adolph

A reactive oxygen species savaging emulsion; the emulsion comprising an injectable pharmaceutically acceptable composition and a polymeric poly(propylene sulfide) microsphere for targeted delivery to a site with elevated reactive oxygen species. In embodiments of the present invention, the microsphere is loaded with a biologically active agent.

Reactive oxygen species (ROS)-responsive compositions and methods thereof

The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.

Polymeric nanoparticles

Growing community of inventors

Nashville, TN, United States of America

Christopher E Nelson