Smithkline Beecham Corporation

Smithkline Beechman Corporation

Christopher Donald Southan

Nicola Anne Burgess

Kristine Kay Kikly

Deirdre Mary Bernadette Hickey

Colin Houston MacPhee

Conrad Gerald Chapman

David Graham Tew

Israel Simon Gloger

Helen Elizabeth Clinkenbeard

Joanne Rachel Evans

Simon Quentyn John Rice

Anne M Knab

Geoffrey Mark Prouse Lawrence

David J Powell

The enzyme Lp-PLAin purified form, an isolated nucleic acid molecule encoding Lp-PLA, the use of an inhibitor of the enzyme Lp-PLAin therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy

The enzyme Lp-PLAin purified form, an isolated nucleic acid molecule encoding Lp-PLA, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

The hRCE1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hRCE1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Human RCE1

MPROT12 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MPROT12 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

MPROT12 polynucleotides and methods thereof

METPRO02 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing METPRO02 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Compounds

The enzyme Lp-PLA,in purified form, an isolated nucleic acid molecule encoding Lp-PLA,, the use of an inhibitor of the enzyme Lp-PLA,in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

The HE2NW40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE2NW40 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

ASP1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP1 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimers's Disease, cancer, and melanoma, among others, and diagnostic assays for such conditions.

ASP1

HGBAB90 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HGBAB90 polypeptides and polynucleotides in the design of protocols for the treatment of pulmonary emphysema, arthritis, multiple sclerosis, periodontal disease, cystic fibrosis, respiratory disease, thrombosis, cancer, cachexia, angina, glaucoma, inflamatory disorders, osteoporosis, cardiovascular disorders such as hypertension, atherosclerotic disorders such as cardiac infarction, and stroke, asthma, psoriasis, chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, demyelinating diseases, AIDS immune deficiency, disorders of photoreceptor degeneration, and lens cataract formation, organ transplant rejection, cataracts, restenosis, muscular dystrophy, renal failure, cerebral vasospasm, pancreatitis, and diabetic nephropathy, among others, and diagnostic assays for such conditions.

HTEGU07 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTEGU07 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

The hAFC1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hAFC1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Growing community of inventors

London, United Kingdom

Christopher Donald Southan