The Charles Stark Draper Laboratory, Inc.

Children's Medical Center Corporation

Johnson & Johnson Innovation LLC

Christopher Dibiasio

Jeffrey T Borenstein

Samir A Nayfeh

Alexander H Slocum

Joseph L Charest

Daniel I Harjes

Pedro J Del Nido

Ernest Soonho Kim

Martin Nohilly

Nikolay V Vasilyev

Keith Durand

Alla Epshteyn

Zach Traina

Mark Laurenzi

Jonathan Wilson

Vijaya Kolachalama

Jon Hopkins

Kevin Hufford

Violet Finley

Ricky Soong

A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets.

Systems and methods for increasing convective clearance of undesired particles in a microfluidic device

Growing community of inventors

Stoughton, MA, United States of America

Christopher Dibiasio