Thermo Scientific Portable Analytical Instruments Inc.

Ahura Scientific Inc.

Veralight, Inc.

Ahura Corporation

Inlight Solutions, Inc.

Christopher D Brown

Kevin J Knopp

Daryoosh Vakhshoori

Gregory H Vander Rhodes

Masud Azimi

Peidong Wang

Peili Chen

Arran M Bibby

John D Maynard

Robert D Johnson

Marwood Neal Ediger

Edward L Hull

Robert L Green

Brendon D Tower

Stephen McLaughlin

Gregory Vander Rhodes

Myrle E Sieger, Iii

Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine information about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.

System for determining a composition of a sample using wavelength dependent variability measurement with multiple time intervals

Optical scanning systems and methods for measuring a sealed container with a layer for reducing diffusive scattering

Disclosed herein are methods and systems for scanning objects and associated substances, where the methods include: (a) using a first electronic device to scan a feature of an object and provide reference information about the object based on the scanned feature, where the feature identifies the object or a substance associated with the object; (b) using a second electronic device to measure electromagnetic radiation emitted from the object and provide sample information about the object based on the measured electromagnetic radiation; and (c) comparing the sample information and the reference information to determine whether the object includes the substance associated with the object.

Object scanning and authentication

We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

Handheld infrared and raman measurement devices and methods

This disclosure relates to a method that includes receiving infrared adsorption absorption information for a sample, processing the infrared adsorption absorption information for the sample to determine an identity of the sample, generating a reference signature for the identified sample, and distributing the reference signature for the identified sample to a plurality of handheld measurement devices via cellular connections with the handheld measurement devices.

Supporting remote analysis

A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

Determination of a measure of a glycation end-product or disease state using tissue fluorescence preferentially from the dermis

We disclose an apparatus comprising: a hand-portable optical analysis unit including an optical interface; and a device configured to receive and releasably engage the hand-portable optical analysis unit. The device comprises: a housing; a sample unit in the housing; and a resilient member configured to bias the sample unit and the hand-portable analysis unit towards each other when the hand-portable optical analysis unit is received in the device to compress a sample disposed between the sample unit and the optical interface of the optical analysis unit. Methods of analyzing samples are also disclosed.

Preparing samples for optical measurement

Determination of a measure of a glycation end-product or disease state using tissue fluorescence

Methods for determining the most likely composition of sample are disclosed. The methods can include: obtaining data from a sample, where the data includes a representation of a measured spectrum; determining a precision state of the representation of the measured spectrum; providing a plurality of library candidates; for each library candidate, providing data representing each library candidate, where the data includes a representation of a library spectrum; determining a representation of the similarity of the sample to each library candidate; determining the most likely composition of the sample based upon the determined representations of similarity of the sample to each library candidate; and displaying the most likely composition of the sample to a user.

Methods and systems for determining sample identity information are disclosed

Handheld infrared and Raman measurement devices and methods

A method for determining the most likely composition of a sample, including obtaining data from a sample, wherein the data includes a representation of a measured spectrum; determining the precision state of the representation of the measured spectrum; providing a plurality of library candidates and, for each library candidate, providing data representing each library candidate, wherein the data includes a representation of a library spectrum; determining a representation of the similarity of the sample to each library candidate using (i) the representation of the measured spectrum; (ii) the precision state of the representation of the measured spectrum; and (iii) the representation of the library spectrum for that library candidate; determining the most likely composition of the sample based upon the determined representations of similarity of the sample to each library candidate; and displaying the most likely composition of the sample to a user.

Spectrum searching method that uses non-chemical qualities of the measurement

Methods of reducing the effects of measurement device artifacts on a measurement of a sample are presented. A number of reference measurements performed with the measurement device are observed to identify reference independent components of the reference measurements. The variations of the reference independent components are used as surrogates for possible artifacts of the measurement device. A number of measurements of subjects similar to the sample are observed, and similarity components of the subject measurements that vary in a manner similar to the reference independent components may be identified. The sample measurement is then adjusted to remove at least part of the similarity components that correspond to the variations in the reference independent components. The adjustment of the sample measurement is thereby improved by reducing the effects of artifacts of the measurement device.

Growing community of inventors

Haverhill, MA, United States of America

Christopher D Brown