Verve Therapeutics, Inc.

Christopher Cheng

Kallanthottathil G Rajeev

Caroline Reiss

Alexandra Chadwick

Ellen Rohde

Provided herein are compositions and methods for preparation of 5' end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5′ end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.

Compositions and methods for capping RNAS

Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.

Growing community of inventors

North Reading, MA, United States of America

Christopher Cheng