University of Rochester

Simpore Inc.

Adarza Biosystems, Inc.

Christopher C Striemer

Nestor O Farmiga

Benjamin L Miller

Philippe M Fauchet

James McGrath

Thomas R Gaborski

Jon-Paul DesOrmeaux

Andrew Murnan

James A Roussie

Joshua J Miller

Jared A Carter

Jon-Paul S Desormeaux

Wade Campney

Emily J Triplett

Provided are monolithic structures comprising one or more suspended, nanoporous membranes that are in contact with one or more fluidic cavities, methods of making same, and exemplary uses of same. The monolithic structures can be formed using a transmembrane etch. The monolithic structures can be used, as examples, as filters and filtration modules in microfluidic devices, dialysis devices, and concentration devices in laboratory, industrial, and medical processes.

Methods for creating fluidic cavities by transmembrane etching through porous membranes and structures made thereby and uses of such structures

This present disclosure generally relates to devices, methods, and systems for producing large numbers of SiOcoated silicon chips with uniform film thickness controlled to angstrom and sub angstrom levels. The disclosure further relates to etching plates configured for receiving a plurality of chips mounted thereon.

Methods and devices for the high-volume production of silicon chips with uniform anti-reflective coatings

Provided are nanoporous silicon nitride membranes and methods of making such membranes. The membranes can be part of a monolithic structure or free-standing. The membranes can be made by transfer of the nanoporous structure of a nanoporous silicon or silicon oxide film by, for example, reactive ion etching. The membranes can be used in, for example, filtration applications, hemodialysis applications, hemodialysis devices, laboratory separation devices, multi-well cell culture devices, electronic biosensors, optical biosensors, active pre-concentration filters for microfluidic devices.

Nanoporous silicon nitride membranes, and methods for making and using such membranes

Provided is a free-standing silicon oxide film that is under tensile stress. Also, provided are methods of making a free-standing silicon oxide film that is under tensile stress. The methods use low-power PECVD deposition of silicon oxide. Methods of imaging one or more objects (e.g., cells) using a free-standing silicon oxide film that is under tensile stress is also provided.

Free-standing silicon oxide membranes and methods of making and using same

A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor material; masking an opposite side of the substrate; etching the substrate, beginning from the masked opposite side of the substrate and continuing until a passage is formed through the substrate, thereby exposing the film on both sides thereof to form a membrane; and then simultaneously forming a plurality of randomly spaced pores in the membrane. The resulting porous nanoscale membranes, characterized by substantially smooth surfaces, high pore densities, and high aspect ratio dimensions, can be used in filtration devices, microfluidic devices, fuel cell membranes, and as electron microscopy substrates.

Ultrathin porous nanoscale membranes, methods of making, and uses thereof

Disclosed is a device for co-culturing two or more populations of cells using ultrathin, porous membranes positioned between cell culture chambers. Multiple chamber devices and uses thereof are described, including the formation of in vitro tissue models for studying drug delivery, cell-cell interactions, and the activity of low abundance molecular species.

Cell culture devices having ultrathin porous membrane and uses thereof

A nanoscale membrane exposed on opposite sides thereof and having an average thickness of less than about 100 nm, and a lateral length to thickness aspect ratio that is more than 10,000 to 1 is disclosed. Also disclosed are methods of making such membranes, and use thereof in a number of devices including fuel cells, sensor devices, electrospray devices, and supports for examining a sample under electron microscopy.

Ultrathin nanoscale membranes, methods of making, and uses thereof

A method of sensing at least one target on a receptor having a substrate and a translucent coating includes minimizing interference fringe patterns in an image of the target. The method also includes passing the image of the target through an imaging system intermediate the receptor and a detector.

Growing community of inventors

Rochester, NY, United States of America

Christopher C Striemer