Musc Foundation for Research Development

The United States Government As Represented by the Department of Veterans Affairs

Peterson, Yuri Karl

Rohrer, Baerbel

Beeson, Craig, C.

Lindsey, Christopher, C.

Christopher C Lindsey

Craig Cano Beeson

Yuri Karl Peterson

Baerbel Rohrer

Rick G Schnellmann

John J Lemasters

Andaleb I Kholmukhamedov

Craig C Beeson

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.

5HT1F receptor agonists and mitochondrial biogenesis

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease. 

In some aspects, the present invention relates to aza-ellipticine compounds of the formula: wherein the variables are as defined herein. The application also provides novel methods of preparing aza-ellipticine compounds, methods of using the compounds, and pharmaceutical compositions thereof. 

Aza-ellipticine analogs, methods of synthesis and methods of treatment

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders. 

Oxindole compounds and pharmaceutical compositions thereof

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders

Provided herein is a fluorescent probe compound of formula (I): as well as methods of using said compound.

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Wadmalaw Island, SC, United States of America

Christopher C Lindsey