University of Pittsburgh

Soliton, Inc.

Other

The University of Texas System

Biointerface Technologies, Inc.

Snf Sa

Markwell Medical Institute, Inc.

Christopher C Capelli

Harold E Swift

Marlin H Mickle

Michael B Chancellor

Johnny Huard

David Robertson

Charles Edward Greene

Zhuqing Qu

Minhong Mi

Allen Wayne Burton

Phillip C Phan

Michael S Sacks

Leonid Matts

Steve Chung

Walter Klemp

Robert J Crowley

Eric John Beckman

Stuart J Updike

Cedrick Favero

Hong Koo Kim

Zhijun Sun

Robert Crowley

Daniel Masse

Mark C Shults

Leonid Mats

William Eamon Carroll

Toby Chapman

Hatice Ozsoy

John Summerson

Jeremiah Palmer

Ali Shajii

Tody M Chapman

Kevin Zamzow

Mark G Shults

Zhuqing Qu-Petersen

Michael Kishinevsky

Michael B, Chancellor

Apparatuses and methods for generating therapeutic compressed acoustic waves (e.g., shock waves) with an improved acoustic wavefront. In the apparatuses, a housing is defined by a chamber and a shockwave outlet, the chamber is configured to be filed with liquid, a plurality of electrodes defining one or more spark gaps and an acoustic reflector can disposed in the chamber, and a pulse generation system configured to apply voltage pulses to the electrodes at a rate of between 10 Hz and 5 MHz. The improved acoustic wavefront is achieved via a free-form acoustic reflector and/or a stable spark gap location. The free-form acoustic reflector is designed according to a disclosed method including iterating reflector shape using spline interpolation based on defined variables. Additionally, a stable spark gap location is achieved via a single servomotor that adjusts both electrodes simultaneously.

Rapid Pulse electrohydraulic (EH) shockwave generator apparatus with improved acoustic wavefronts

Methods and systems for method for acoustic treatment of tissue to disperse vacuoles within the tissue. Some of the present methods and systems comprise: directing pulsed acoustic waves from the acoustic wave generator into the tissue containing the vacuoles. Some of the present methods include identifying the location of tissue containing vacuoles, and/or coupling (e.g., acoustically) an acoustic wave generator to the tissue containing the vacuoles.

Pulsed acoustic wave dermal clearing system and method

Embodiments of the present disclosure are directed to systems, devices, and methods of inducing physical effects in tissue, such as dermis, adipose, musculoskeletal, vascular, hepatic tissue, using unfocused or planar, non-cavitating acoustic shock waves. The physical effects include disruption of fibrous extracellular matrix of the targeted tissues. Embodiments of the present disclosure include applying rapid acoustic pulses (e.g., shock waves) to cause a breakdown in the fibrous extracellular matrix to reduce the appearance of cellulite or scars in a treatment area. Such unfocused or planar, non-cavitating acoustic shock waves may induce a tissue reaction, such as reduction of fibrosis, induction of angiogenesis, or lymphangiogenesis.

Systems, devices, and methods of treating tissue and cellulite by non-invasive acoustic subcision

Apparatuses and methods to generate high frequency shock waves in a controlled manner. The generated shock waves can be delivered to certain cellular structures of a patient for use in medical and/or aesthetic therapeutic applications. The shock waves can be configured to impose sufficient mechanical stress to the targeted cells of the tissue to rupture the targeted cells. Embodiments of the apparatuses and methods of the present invention provide targeted rupturing of specific cells without damaging side effects such as cavitation or thermal degradation of surrounding non-targeted cells.

Apparatus for generating therapeutic shockwaves and applications of same

Apparatuses, capacitor arrays, and methods for generating therapeutic compressed acoustic waves (e.g., shock waves). In the apparatuses and at least some of the methods, a plurality of electrodes can disposed in a chamber that is defined by a housing and configured to be filled with liquid, and a plurality of capacitors can be electrically connected to the electrodes and can be carried by (e.g., physically coupled to) the housing. Voltage pulses can be applied simultaneously to the plurality of electrodes (e.g., to begin to vaporize and ionize portions of the liquid to provide at least one inter-electrode conductive path between the plurality of electrodes) and to the capacitors to charge the plurality of capacitors). The plurality of capacitors can be configured to, upon reaching a threshold charge, discharge to the plurality of electrodes (e.g., to generate one or more arcs along the one or more inter-electrode conductive paths to vaporize additional portions of the liquid and generate one or more acoustic shock waves). In the capacitor arrays, a plurality of capacitors can be coupled to the one or more circuit boards with a first portion of the capacitors arranged in a first pattern defined by a plurality of capacitor sets, a second portion of the plurality of capacitors can be arranged in a second pattern defined by a plurality of capacitor sets, with the sets defining the first pattern connected in parallel, the sets defining the second pattern connected in parallel, and the circuit board(s) can be configured to be coupled to an electrode such that the electrode is in electrical communication with the capacitors and is fixed in at least two degrees of freedom relative to the one or more circuit boards.

Rapid pulse electrohydraulic (EH) shockwave generator apparatus with improved electrode lifetime

Apparatuses and methods for selectively providing laser induced optical breakdown (LIOB) of absorptive targets in biological media. For example, LIOB may be used as part of tissue therapy, such as cosmetic therapy associated with tattoo removal. In some implementation, a system for selectively providing LIOB includes a field generator configured to generate a field and to apply the field through a portion of a biological medium. The system also includes a light source configured to deliver laser light to the portion of the biological medium during application of the field. Application of the field to the biological medium induces movement of free electrons within the portion of the biological medium which may reduce or slow the formation of vacuoles in the biological medium responsive to the laser light.

Selective laser induced optical breakdown in biological medium

Apparatuses and methods for generating therapeutic shock waves. Some embodiments comprise: an acoustic-wave generator configured to emit acoustic waves having at least one frequency between 1 MHz and 1000 MHz; a shock wave housing coupled to the acoustic-wave generator; and a shock wave medium disposed in the shock wave housing; where the apparatus is configured such that if the acoustic-wave generator emits acoustic waves then at least some portion of the acoustic waves will travel through the shock wave medium and form one or more shock waves.

Apparatuses and systems for generating high-frequency shockwaves, and methods of use

Embodiments of the present disclosure are directed to methods of inducing therapeutic adipose tissue inflammation using high frequency pressure waves (e.g. high frequency shockwaves) wherein the inflammation results in a reduction in the volume of subcutaneous adipose tissue. Embodiments include applying electrohydraulic generated shockwaves at a rate of between 10 Hz and 100 Hz to reduce the appearance of cellulite or the volume of subcutaneous fat in a treatment area.

Methods of treating cellulite and subcutaneous adipose tissue

Apparatuses and methods for electrohydraulic generation of Shockwaves at a rate of between 10 Hz and 5 MHz, and/or that permit a user to view a region of a patient comprising target cells during application of generated Shockwaves to the region. Methods of applying electro-hydraulically generated Shockwaves to target tissues (e.g., for reducing the appearance of tattoos, treatment or reduction of certain conditions and/or maladies).

Rapid pulse electrohydraulic (EH) shockwave generator apparatus and methods for medical and cosmetic treatments

Apparatuses and methods for electrohydraulic generation of shockwaves at a rate of between 10 Hz and 5 MHz, and/or that permit a user to view a region of a patient comprising target cells during application of generated shockwaves to the region. Methods of applying electro-hydraulically generated shockwaves to target tissues (e.g., for reducing the appearance of tattoos, treatment or reduction of certain conditions and/or maladies).

The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.

Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief

A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications. The stem cells can be from numerous sources and may be homogeneous, heterogeneous, autologous, and/or allogeneic in the matrix material. The stem cell-matrix compositions provide point of service utility for the practitioner, wherein the stem cells and matrix can be combined not long before use, thereby alleviating costly and lengthy manufacturing procedures. In addition, the stem cells offer unique structural properties to the matrix composition which improves outcome and healing after use. Use of stem cells obtained from muscle affords contractility to the matrix composition.

Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair

The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery, hi certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.

The present invention provides methods for reducing pain in a subject in need thereof by delivering a volatile anesthetic in a solution or an emulsion that can additionally include an extractive solvent in an amount effective to reduce pain without substantially interfering with motor function. Chronic or acute pain may be treated, or the volatile anesthetic may be delivered as a regional anesthetic to a subject to anesthetize a portion of the subject prior to surgery. Dosing regimes including a one-time administration, continuous and/or periodic administration are contemplated.

Volatile anesthetic compositions and methods of use

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

Growing community of inventors

Kenosha, WI, United States of America

Christopher C Capelli